IMPACT OF COMBINATORY BLOCKADE OF VASODILATORS IN FOREARM EXERCISE

血管扩张剂联合阻断对前臂运动的影响

• 批准号: 7625786
• 负责人: URS A LEUENBERGER
• 金额: $ 1.42万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625786
• 关键词: Adenosine; Aminophylline; Attenuated; Computer Retrieval of Information on Scientific Projects Database; Exercise; Forearm; Funding; Grant; Individual; Institution; Mediator of activation protein; Nitric Oxide; Nitric Oxide Synthase; Physiological; Protocols documentation; Purinergic P1 Receptors; Research; Research Personnel; Resources; Source; Testing; Thinking; United States National Institutes of Health; Vasodilation; Vasodilator Agents; inhibitor/antagonist; omega-N-Methylarginine; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this protocol is to test the impact of individual and combined blockade of adenosine (with the adenosine-receptor inhibitor aminophylline) and nitric oxide (with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine, L-NMMA) on rapid vasodilation during and after forearm exercise. Because adenosine and nitric oxide are thought to be important physiologic mediators of vasodilation, we hypothesize that combined blockade of these vasodilators would act to delay and/or attenuate anticipated vasodilatory responses after exercise.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案的主要目的是测试单独和联合阻断腺苷(与腺苷受体阻滞剂氨茶碱)和一氧化氮(与一氧化氮合酶抑制剂NG-单甲基-L-精氨酸，L-NMMA)在前臂运动中和之后对快速血管扩张的影响。由于腺苷和一氧化氮被认为是血管扩张的重要生理介质，我们假设联合阻断这些血管扩张剂将延迟和/或减弱运动后预期的血管扩张反应。