PG SYNTHESIS INHIBITION ON VASODILATOR CAPACITY W REACTIVE HYPEREMIA & HYPOXIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine whether the relative activity of metabolic vasodilator pathways is altered in patients with obstructive sleep apnea (OSA). The specific aims of this protocol are to determine: 1) The maximal vasodilator capacity (reactive hyperemic blood flow response, RHBF); 2) The vasodilatory responses to hypoxia; 3) The effects of prostaglandin synthesis inhibition on RHBF; 4) The effects of prostaglandin synthesis inhibition on hypoxia-induced vasodilation in OSA .