INTERMITTENT HYPOXIA NEUROCIRCULATORY RESPONSE TO CHEMOREFLEX & EXERCISE REFLEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定低氧应激对健康人体交感神经活动和血流的调节作用。短暂低氧显著增加交感神经活性并引起血管扩张，而间歇性低氧往往引起持续的交感神经兴奋和增强的化学反射敏感性。本研究的工作假设是，间歇性低氧与短暂性低氧相比，会兴奋交感神经系统，改变交感神经反射功能，并唤起血管功能的代偿性适应，从而在低氧期间对抗交感血管收缩张力。此外，运动训练会减少这种影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to determine the role of hypoxic stress on the regulation of sympathetic activity and blood flow in healthy humans. Transient hypoxia acutely increases sympathetic activity and evokes vasodilation while intermittent hypoxia tends to evoke sustained sympathoexcitation and enhanced chemoreflex sensitivity. The working hypothesis of this study is that intermittent hypoxia compared to transient hypoxia will excite the sympathetic nervous system, alter sympathetic reflex function and evoke compensatory adaptations of vascular function that oppose sympathetic vasoconstrictor tone during hypoxia. Further, exercise training will reduce this effect.