INTERMITTENT HYPOXIA NEUROCIRCULATORY RESPONSE TO CHEMOREFLEX & EXERCISE REFLEX
INTERMITTENT HYPOXIA NEUROCIRCULATORY RESPONSE TO CHEMOREFLEX & EXERCISE REFLEX
批准号:
7951302
负责人:
URS A LEUENBERGER
金额:
$0.23万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-01 至 2010-03-31
关键词:
Blood VesselsBlood flowClinical ResearchComputer Retrieval of Information on Scientific Projects DatabaseExerciseFundingGoalsGrantHumanHypoxiaInstitutionReflex actionRegulationResearchResearch PersonnelResourcesRoleSourceStressSympathetic Nervous SystemTrainingUnited States National Institutes of HealthVasoconstrictor AgentsVasodilationWorkresponse
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
本研究的目的是确定低氧应激对健康人交感神经活性和血流调节的作用。 短暂性低氧急性增加交感神经活性并引起血管舒张,而间歇性低氧倾向于引起持续的交感神经兴奋和增强的化学反射敏感性。本研究的工作假设是,与短暂缺氧相比,间歇性缺氧将兴奋交感神经系统,改变交感神经反射功能,并引起血管功能的代偿性适应,对抗缺氧期间的交感血管收缩张力。 此外,运动训练会减少这种影响。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of this study is to determine the role of hypoxic stress on the regulation of sympathetic activity and blood flow in healthy humans. Transient hypoxia acutely increases sympathetic activity and evokes vasodilation while intermittent hypoxia tends to evoke sustained sympathoexcitation and enhanced chemoreflex sensitivity. The working hypothesis of this study is that intermittent hypoxia compared to transient hypoxia will excite the sympathetic nervous system, alter sympathetic reflex function and evoke compensatory adaptations of vascular function that oppose sympathetic vasoconstrictor tone during hypoxia. Further, exercise training will reduce this effect.
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Human Physiology Core Laboratory
-
批准号:8001324
-
项目类别:
-
资助金额:$42.07万
-
财政年份:2010
-
负责人:URS A LEUENBERGER
-
依托单位:
Intermittent Hypoxia: A Model to Study Circulatory Control in Humans
-
批准号:8289590
-
项目类别:
-
资助金额:$15.3万
-
财政年份:2010
-
负责人:URS A LEUENBERGER
-
依托单位:
Intermittent Hypoxia: A model a study circulatory control in humans
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批准号:8001286
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项目类别:
-
资助金额:$31.49万
-
财政年份:2010
-
负责人:URS A LEUENBERGER
-
依托单位:
Intermittent Hypoxia: A Model to Study Circulatory Control in Humans
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批准号:8118512
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项目类别:
-
资助金额:$15.45万
-
财政年份:2010
-
负责人:URS A LEUENBERGER
-
依托单位:
Intermittent Hypoxia: A Model to Study Circulatory Control in Humans
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批准号:7986094
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项目类别:
-
资助金额:$15.45万
-
财政年份:2010
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负责人:URS A LEUENBERGER
-
依托单位:
EFFECTS OF INHIBITORS OF METABOLIC VASODILATION DURING HYPOXIA
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批准号:7951239
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项目类别:
-
资助金额:$0.6万
-
财政年份:2009
-
负责人:URS A LEUENBERGER
-
依托单位:
CARDIAC OUTPUT AND VOLUME EXPANSION
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批准号:7951244
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项目类别:
-
资助金额:$0.37万
-
财政年份:2009
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECT OF SYMP NEURAL BLOCKADE ON REACTIVE HYPEREMIA & RESPONSES IN OSA
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批准号:7625742
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项目类别:
-
资助金额:$0.54万
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财政年份:2007
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负责人:URS A LEUENBERGER
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依托单位:
PG SYNTHESIS INHIBITION ON VASODILATOR CAPACITY W REACTIVE HYPEREMIA & HYPOXIA
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批准号:7625795
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项目类别:
-
资助金额:$0.69万
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财政年份:2007
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负责人:URS A LEUENBERGER
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依托单位:
EXERCISE INTOLERANCE INDUCED BY HYPERTHYROIDISM
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批准号:7625784
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项目类别:
-
资助金额:$1.31万
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财政年份:2007
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECT OF HYPOXIA ON INTERSTITIAL METABOLITES & SKELETAL MUSCLE BLD FLOW IN OSA
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批准号:7625738
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项目类别:
-
资助金额:$0.22万
-
财政年份:2007
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECTS OF INHIBITORS OF METABOLIC VASODILATION DURING HYPOXIA
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批准号:7625754
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项目类别:
-
资助金额:$0.91万
-
财政年份:2007
-
负责人:URS A LEUENBERGER
-
依托单位:
IMPACT OF COMBINATORY BLOCKADE OF VASODILATORS IN FOREARM EXERCISE
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批准号:7625786
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项目类别:
-
资助金额:$1.42万
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财政年份:2007
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负责人:URS A LEUENBERGER
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依托单位:
ACUTE CHANGES IN ARTERIAL STIFFNESS DURING EXERCISE
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批准号:7625808
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项目类别:
-
资助金额:$0.54万
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财政年份:2007
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负责人:URS A LEUENBERGER
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依托单位:
SYMPATHETIC VASOCONSTRICTOR RESPONSIVE DURING SMALL MUSCLE EXERCISE AGE &SEX
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批准号:7625749
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项目类别:
-
资助金额:$2.14万
-
财政年份:2007
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECT OF SYSTEMIC HYPOXIA ON MSNA & ITS RELATIONSHIP TO INTERSTITIAL ADENINE NU
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批准号:7625755
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项目类别:
-
资助金额:$0.15万
-
财政年份:2007
-
负责人:URS A LEUENBERGER
-
依托单位:
ALTERATION OF SYMPATHETIC ACT & BP BY CPAP IN SLEEP APNEA PATIENTS
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批准号:7378437
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项目类别:
-
资助金额:$0.56万
-
财政年份:2006
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECT OF SYMP NEURAL BLOCKADE ON REACTIVE HYPEREMIA & RESPONSES IN OSA
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批准号:7378463
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项目类别:
-
资助金额:$1.72万
-
财政年份:2006
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECT OF SYSTEMIC HYPOXIA ON MSNA & ITS RELATIONSHIP TO INTERSTITIAL ADENINE NU
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批准号:7378486
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项目类别:
-
资助金额:$0.22万
-
财政年份:2006
-
负责人:URS A LEUENBERGER
-
依托单位:
EFFECTS OF INHIBITORS OF METABOLIC VASODILATION DURING HYPOXIA
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批准号:7378485
-
项目类别:
-
资助金额:$0.6万
-
财政年份:2006
-
负责人:URS A LEUENBERGER
-
依托单位:
海外基金