INTERMITTENT HYPOXIA NEUROCIRCULATORY RESPONSE TO CHEMOREFLEX & EXERCISE REFLEX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定低氧应激对健康人交感神经活性和血流调节的作用。 短暂性低氧急性增加交感神经活性并引起血管舒张，而间歇性低氧倾向于引起持续的交感神经兴奋和增强的化学反射敏感性。本研究的工作假设是，与短暂缺氧相比，间歇性缺氧将兴奋交感神经系统，改变交感神经反射功能，并引起血管功能的代偿性适应，对抗缺氧期间的交感血管收缩张力。 此外，运动训练会减少这种影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to determine the role of hypoxic stress on the regulation of sympathetic activity and blood flow in healthy humans. Transient hypoxia acutely increases sympathetic activity and evokes vasodilation while intermittent hypoxia tends to evoke sustained sympathoexcitation and enhanced chemoreflex sensitivity. The working hypothesis of this study is that intermittent hypoxia compared to transient hypoxia will excite the sympathetic nervous system, alter sympathetic reflex function and evoke compensatory adaptations of vascular function that oppose sympathetic vasoconstrictor tone during hypoxia. Further, exercise training will reduce this effect.