CHILDREN'S HEALTH AND NATURAL GROWTH EVALUATION STUDY (CHANGES)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。儿童健康和自然生长评估研究（CHANGES）检查了已经超重的青少年中儿童中期全身脂肪和内脏脂肪（位于腹腔内器官周围的脂肪）积累的自然时间过程。内脏脂肪被认为是成年人体内最有害的脂肪分布类型，但目前还不清楚儿童如何，何时或为什么积累这种类型的脂肪。这项研究旨在确定相对高和低的腹内脂肪积累的特定发育时期，并评估潜在的激素（例如，瘦素，胰岛素）和行为（例如，身体活动，饮食成分）的因素和儿童的身体脂肪分布变化的后果。这是一项为期2年的前瞻性研究，在36名8岁开始参与的超重儿童中进行。评估每六个月进行一次，并与总体脂、体脂分布、体重和发育相关激素以及体重相关行为的测量一致。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Child Health and Natural Growth Evaluation Study (CHANGES) examines the natural time course of total body fat and visceral fat (fat located around the organs within the abdominal cavity) accumulation through middle childhood among already overweight youth. Visceral fat is considered the most harmful type of body fat distribution in adults, but it is unclear how, when, or why children accumulate this type of fat. This study seeks to identify specific developmental periods of relatively high and low intra-abdominal fat accumulation, and to evaluate potential hormonal (e.g., leptin, insulin) and behavioral (e.g., physical activity, dietary components) factors and consequences of children's changing body fat distribution. This is a 2-year prospective study being conducted among 36 overweight children who started participation at age 8. Assessments occur every six months and consistent of measurement of total body fat, body fat distribution, weight- and development-related hormones, and weight-related behaviors.