OBESITY/INSULIN RESISTANCE AND ENDOTHELIAL DYSFUNCTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。糖尿病使心脏病发作和中风的风险急剧增加。先前的研究表明，与2型糖尿病相关的心脏病和中风的大部分风险是在糖尿病发病之前产生的。中老年超重成年人患2型糖尿病和心脏病的风险增加。我们现在知道，排列在血管中的细胞通过释放有助于血管扩张的物质(增大大小以运载更多血液)在预防心脏病方面发挥着重要作用。在肥胖和糖尿病患者中，这些细胞功能不正常，导致扩张和增加血液的能力受损。这一功能的丧失与心脏附着和中风的风险增加有关。这项研究试图确定肥胖成年人血管扩张能力降低的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The risks for heart attach and stroke increases dramatically with diabetes. Prior research indicates that much of the risk for heart disease and stroke associated with type 2 diabetes is generated prior to the onset of diabetes. Middle-aged and older overweight adults are at an increased risk of developing type 2 diabetes and heart disease. We now know that cells that line our blood vessels play an important role in preventing heart disease by releasing substances that help the vessel dilate (increase in size to carry more blood). In obese and diabetic individuals these cells do not function properly resulting in an impaired ability to dilate and increase blood. Loss of this function is associated with an increased risk of heart attach and stroke. This study seeks to determine the mechanism responsible in the reduced ability of blood vessels to vasodilate in obese adults.