AGING, EXERCISE AND ENDOTHELIAL PROGENITOR CELLS

衰老、运动和内皮祖细胞

• 批准号: 7604510
• 负责人: Christopher J de Souza
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604510
• 关键词: Aerobic Exercise; Aging; Arteries; Blood; Computer Retrieval of Information on Scientific Projects Database; Elderly; Exercise; Funding; Grant; Heart; Institution; Purpose; Research; Research Personnel; Resources; Risk; Source; Stem cells; Stroke; United States National Institutes of Health; improved; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With advancing the age the ability of arteries to vasodilate (increase in size to carry more blood) decreases. This is associated with an increased risk of heart attach and stroke. The reasons for this decline are not well understood. Previous studies have shown that regular aerobic exercise can improve the abilities of arteries to vasodilate. The purpose of this study is to determine whether with advancing age arteries are more prone to vasoconstrict (decrease in size) and whether regular aerobic exercise reduces this tendency to vasoconstrict.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 随着年龄的增长，动脉的血管舒张能力（尺寸增大以输送更多血液）会降低。 这与心脏病和中风的风险增加有关。 这种下降的原因尚不清楚。 此前的研究表明，定期进行有氧运动可以提高动脉血管舒张的能力。 本研究的目的是确定随着年龄的增长，动脉是否更容易发生血管收缩（尺寸减小），以及定期的有氧运动是否会减少这种血管收缩的趋势。