AGING, EXERCISE AND ENDOTHELIN-1 VASOCONSTRICTOR TONE

衰老、运动和内皮素 1 血管收缩剂

• 批准号: 7719549
• 负责人: Christopher J de Souza
• 金额: $ 0.48万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719549
• 关键词: Aerobic Exercise; Aging; Arteries; Blood; Computer Retrieval of Information on Scientific Projects Database; Elderly; Endothelin-1; Exercise; Funding; Grant; Heart; Institution; Purpose; Research; Research Personnel; Resources; Risk; Source; Stroke; United States National Institutes of Health; Vasoconstrictor Agents; improved; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With advancing the age the ability of arteries to vasodilate (increase in size to carry more blood) decreases. This is associated with an increased risk of heart attach and stroke. The reasons for this decline are not well understood. Previous studies have shown that regular aerobic exercise can improve the abilities of arteries to vasodilate. The purpose of this study is to determine whether with advancing age arteries are more prone to vasoconstrict (decrease in size) and whether regular aerobic exercise reduces this tendency to vasoconstrict.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 随着年龄的增长，动脉血管扩张的能力（尺寸增加以携带更多血液）下降。 这与心脏病和中风的风险增加有关。 这一下降的原因尚不清楚。 以往的研究表明，有规律的有氧运动可以提高动脉血管扩张的能力。 这项研究的目的是确定随着年龄的增长，动脉是否更容易发生血管收缩（尺寸减小），以及定期有氧运动是否会降低血管收缩的趋势。