OBESITY/INSULIN RESISTANCE, VITAMIN C AND ENDOTHELIN-1

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。随着身体脂肪的增加，动脉扩张血管的能力降低(或增大)，这可能会增加与超重或肥胖相关的心血管疾病的风险。可能导致血管扩张剂能力下降的潜在机制之一是血管收缩倾向的增加(血管大小和/或血管扩张阻力的减少)，这是由一种名为内皮素-1的物质介导的。ET-1的产生和活性的升高与心血管疾病风险的增加有关。这项研究的另一个目的是比较补充维生素C这一安全、廉价的治疗方法和定期有氧运动在降低动脉血管紧张素转换酶倾向方面的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With an increase in body fatness the ability of arteries to "vasodilate"(or increase in size) is reduced which may contribute to an increased risk of cardiovascular diseases associated with being overweight or obese. One of the potential mechanisms that may contribute to this reduced vasodilator capacity is an increased tendency towards vasoconstriction (decrease in size and/or resistance to vasodilation), mediated by a substance called endothelin-1. Elevations in ET-1 production and activity has been linked to an increased risk of cardiovascular disease. An additional aim of this study is to compare the effects of vitamin C supplementation, a safe and inexpensive treatment, and regular aerobic exercise in reducing the tendency of arteries to vasoconstr