COBRE: CORE A: ADMIN CORE; EXPANDING U OF ALASKAS HEALTH RESEARCH CAPABILITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这笔用于建立阿拉斯加土著健康研究中心的科布雷赠款是基于一种基于社区的参与式研究范式，该范式促进了基础研究和应用研究。总体目标是促进一个可持续的、由NIH资助的研究中心的发展，该研究中心专门专注于确定与阿拉斯加原住民体重增加、2型糖尿病和心血管疾病相关的文化行为、营养和遗传风险/保护因素。行政核心提供基础设施，在偏远的阿拉斯加原住民农村社区中支持这项研究。行政核心在第五年取得的成就包括：a.获得三个新村的批准以收集数据。所有这些村庄在历史上都与那些已经抽样的村庄有重要的关系；因此，许多人与目前的参与者有关系。这将增加我们的样本进行基因分析的能力。B.为竞争性更新确定了五名预期的调查员，他们的建议已得到选管会的批准，并确定了支持这些项目的核心结构。得到了各村庄对重建工作的支持，表明他们愿意参与继续研究。在介绍了第一轮数据收集的结果后，与我们的社区合作伙伴计划了续签。C.我们已经获得了大学对更新所需的空间和职位的持续支持，这将使我们能够建立一个长期的生物医学研究计划。当新的国家研究资金可用时，该大学已将生物医学研究作为其最优先资助的项目之一。D.基础设施已发展到60多名全职和兼职调查人员和支持人员。这一能力使我们能够招募907名Yupéik参与者参加这项研究。它刺激了一份R01、一份R24、两份R21、一份R03和一份R34的提交。CANHR调查人员收到了四项R系列赠款。E.自数据分析取得充分进展以来，CANHR调查人员的生产力显著提高。他们在国家和地区会议上提交了60篇摘要，出版了20篇文章或书籍，发表了21篇文章或书籍章节，目前有12篇文章提交审查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This COBRE grant to establish the Center for Alaska Native Health Research is based upon a community-based participatory research paradigm that fosters basic and applied research. The overall goal is to facilitate the development of a sustainable, NIH-funded research center specifically focused on identifying the cultural-behavioral, nutritional, and genetic risk/protective factors associated with increased weight, type two diabetes, and cardiovascular disease among Alaska Natives. The Administrative core provides infrastructure to support this research among remote rural Alaska Native communities. Accomplishments of the Administrative core for year five include: A. Received approval from three new villages to gather data. All of these villages have significant relationships historically to those villages already sampled; therefore, many individuals are related to current participants. This will increase the power of our sample for genetic analyses. B. Identified five prospective investigators for the competitive renewal whose proposals have been approved by the EAC and identified the core structures to support these projects. Received support from the villages for the renewal indicating their willingness to participate in continued research. Planned the renewal with our community partners after presenting results of the first round of data gathering. C. We have secured the continued support of the University for the space and positions needed for the renewal, which will allow us to build a long-term biomedical research program. The university has made biomedical research one of its top funding priorities when new state research dollars become available. D. Infrastructure has grown to over 60 full- and part-time investigators and support staff. This capacity has allowed us to enroll 907 Yup¿ik participants in the study. It has stimulated submissions of one R01, one R24, two R21s, one R03, and one R34. Four R-series grants were received by CANHR investigators. E. Productivity of CANHR investigators has significantly increased since data analysis has progressed adequately. They have presented 60 abstracts at national and regional conferences, have 20 articles or books in press, had 21 articles or book chapters published, and currently have 12 articles submitted for review.