Investigating Obesity and Chronic Disease-Related Risk Factors of Alaska Natives

调查阿拉斯加原住民的肥胖和慢性病相关危险因素

• 批准号: 7848438
• 负责人: Gerald Mohatt
• 金额: $ 3.06万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-08 至 2010-06-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848438
• 关键词: Investigating; Obesity; Chronic; Disease; Related

DESCRIPTION (provided by applicant): The overall goal of the proposed COBRE-funded Center for Alaska Native Health Research (CANHR) is to achieve a permanent and sustainable research center at the University of Alaska Fairbanks (UAF) with the primary theme of investigating obesity and chronic disease-related risk, control, and prevention among Alaska Natives. Specific Aim 1. To enhance the biomedical research infrastructure for Alaska Native health research at the University of Alaska. This will be achieved through an increase in the University's commitment to biomedical research with Alaska Natives, additional research opportunities through an expansion of the number of Alaska Native research sites, formation of statewide research partnerships; and strengthening the integrated organizational structure for COBRE II research. Standing cores have been strengthened and functions consolidated; a Nutrition and Physical Activity Core has been added. The cores are aligned with the long-term CANHR research agenda. Specific Aim 2. Increase the number of investigators at the University of Alaska receiving NIH independent investigator funding for CANHR-related research. This will be achieved by completing four research projects by highly talented new CANHR investigators. Investigators are pursuing research that 1) develops a cultural understanding of the perceptions of weight and diabetes etiology and their relationships to health among Yup'ik Eskimos; 2) investigates a methodology of unbiased biomarkers of dietary intake based on variations in food stable isotope ratios and compares those biomarkers to concurrent diet records; 3) determines nutrients and contaminants in Yup'ik subsistence food sources; and 4) understands more precisely and measures stressors and coping methods among Yup'ik Eskimos. Each investigation will provide a more differentiated understanding of health disparities of Alaska Natives. They will serve as the basis for applications to NIH and a foundation for prevention, applied, and basic research into Alaska Native health disparities. CANHR will increase capacity and strengthen its mentorship ability by hiring two Associate Professors with a record of success in NIH funding. CANHR contributes to the public health of the Alaskan population by identifying risk and protective factors for chronic diseases among an underserved population. Results have implications for understanding the causes and contributing factors of health disparities of other rural minorities in America and in the circumpolar North. They have the potential for translation into additional research that will develop evidence-based practices for primary and secondary prevention. The COBRE provides a foundation for sustaining a research environment with a mission of utilizing research to influence policy and practices that can reduce health disparities.

描述（由申请人提供）：拟议的COBRE-funded阿拉斯加土著健康研究中心（CANHR）的总体目标是实现一个永久性和可持续的研究中心在阿拉斯加大学费尔班克斯（UAF）与调查肥胖和慢性疾病相关的风险，控制和预防阿拉斯加原住民的主要主题。具体目标1.加强阿拉斯加大学阿拉斯加土著人健康研究的生物医学研究基础设施。这将通过增加大学对阿拉斯加原住民生物医学研究的承诺来实现，通过扩大阿拉斯加原住民研究地点的数量来增加研究机会，形成全州范围的研究伙伴关系;以及加强COBRE II研究的综合组织结构。常设核心得到加强，职能得到巩固;增加了营养和体育活动核心。这些核心与CANHR的长期研究议程保持一致。具体目标2。增加阿拉斯加大学接受NIH独立调查员资助的CANHR相关研究的调查员人数。这将通过由才华横溢的新CANHR调查人员完成四个研究项目来实现。调查人员正在进行的研究是：1）在爱斯基摩人中，发展对体重和糖尿病病因及其与健康关系的认识的文化理解; 2）基于食物稳定同位素比率的变化，调查饮食摄入的无偏见生物标志物的方法，并将这些生物标志物与同期的饮食记录进行比较; 3）确定Yup'ik维生食物来源中的营养素和污染物; 4）更准确地理解和测量Yupik爱斯基摩人的压力源和应对方法。每项调查都将对阿拉斯加土著人的健康差异提供更有区别的理解。它们将作为申请NIH的基础，并为阿拉斯加土著人健康差异的预防，应用和基础研究奠定基础。CANHR将通过聘请两名在NIH资助方面有成功记录的副教授来提高能力并加强其指导能力。CANHR通过在得不到充分服务的人口中确定慢性病的风险和保护因素，为阿拉斯加人口的公共卫生做出贡献。研究结果对了解美国和北极圈其他农村少数民族健康差异的原因和影响因素具有重要意义。它们有可能转化为更多的研究，为初级和二级预防制定循证做法。COBRE为维持研究环境提供了一个基础，其使命是利用研究来影响政策和实践，以减少健康差距。