Training in Radiation Oncology Translational Research

放射肿瘤学转化研究培训

• 批准号: 7486811
• 负责人: ROSS B MIKKELSEN
• 金额: $ 20.16万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486811
• 关键词: Radiation Oncology; Training; Translational Research

DESCRIPTION (provided by applicant): This program supports research training at the pre-doctoral and post-doctoral levels in radiation biology, medical physics and imaging relevant to radiation oncology. The program (1 predoctoral, 4 postdoctoral students) consists of 3 years support for post-doctoral students and 2-3 years for graduate students (the first 2 years are covered by the University). Pre-doctoral candidates are selected from interested MD/PHD students and graduate students in the VCU Medical Physics PHD program. Post-doctoral candidates are recruited from Radiation Oncology and Radiology residents with an interest in translational research and from individuals identified by normal recruitment mechanisms with interests in radiation biology and physics as applied to radiation oncology. There are 11 faculty preceptors with NIH funding in medical physics, imaging and cellular biology. Students are introduced to general aspects of cancer and radiation biology through lecture series and in formal courses offered in the Department, the basic science departments and at the NCI designated Massey Cancer Center. Students take a course in scientific ethics. Training in radiological physics includes formal courses in dosimetry, diagnostic imaging and instrumentation, and mentored research in intensity modulated radiotherapy, brachytherapy and diagnostic imaging. For biology students, mentored research in modern radiobiology includes DNA repair mechanisms, radiation-induced signal transduction mechanisms, and reactive oxygen/nitrogen biology. An emphasis in training is on the translational aspects of their research and this is accomplished through the strong translational research program in the Department of Radiation Oncology at VCU including Phase I gene therapy trials and courses in biostatistics focused on clinical and animal trials. The NIH-funded medical physics grants are translational in nature. The Department's Program Project Grant emphasizes modern molecular biological approaches to identifying targets for radiosensitization and validating these targets in vivo in animal studies. Bringing the results from research to applications in the clinic ("bench to bedside") is a major goal of the National Cancer Institute. To achieve this goal requires that the scientists and physicians alike are adequately trained in translational research. The purpose of this program is to provide research training in radiation oncology with an emphasis on the translational aspects for both physician and scientist.

描述（由申请人提供）：该计划支持在博士前和博士后水平的放射生物学，医学物理学和放射肿瘤学相关成像的研究培训。该计划（1名博士预科生，4名博士后学生）包括3年的博士后学生支持和2-3年的研究生支持（前2年由大学负责）。博士前候选人是从感兴趣的MD/PHD学生和研究生在VCU医学物理PHD计划选择。博士后候选人从放射肿瘤学和放射学居民中招募，对转化研究感兴趣，并从正常招募机制中确定的个人中招募，对放射生物学和物理学感兴趣，适用于放射肿瘤学。有11个教师导师与美国国立卫生研究院的资金在医学物理学，成像和细胞生物学。学生通过系列讲座和在部门，基础科学部门和NCI指定的梅西癌症中心提供的正式课程介绍癌症和辐射生物学的一般方面。学生们学习科学伦理学课程。放射物理学的培训包括剂量测定、诊断成像和仪器方面的正式课程，以及强度调制放射治疗、近距离放射治疗和诊断成像方面的指导研究。对于生物学学生来说，现代放射生物学的指导研究包括DNA修复机制、辐射诱导的信号传导机制和活性氧/氮生物学。培训的重点是他们研究的转化方面，这是通过VCU放射肿瘤学系强大的转化研究计划完成的，包括I期基因治疗试验和生物统计学课程，重点是临床和动物试验。美国国立卫生研究院资助的医学物理学赠款本质上是翻译的。该部门的计划项目补助金强调现代分子生物学方法，以确定放射增敏的目标，并在动物研究中验证这些目标。将研究结果应用于临床（“从实验室到床边”）是美国国家癌症研究所的一个主要目标。为了实现这一目标，科学家和医生都需要在转化研究方面得到充分的培训。该计划的目的是提供放射肿瘤学的研究培训，重点是医生和科学家的翻译方面。