Cerebrovascular Research Training Program

描述(由申请人提供)：这项建议是一个新的高度集中的脑血管疾病博士后培训计划，将以西奈山医学院和西奈山中风和医学中心内的西奈山医学院和生物科学研究生院的神经科、神经外科、神经科学和急诊医学系为基础。已经培育和巩固了非常强大的部门间和多学科合作，来自国家卫生研究院的外部资金呈指数级增长。基于丰富和不断扩大的研究存在，以及建立的、积极的和有竞争力的培训部分，我们寻求在这些部门内这一已被证明实力的领域内，将下一代医生和研究科学家的研究培训和职业发展正规化。我们已经采取了多个具体步骤，以确保临床和基础教师导师之间的计划具有凝聚力。考虑到中风引起的疾病的巨大负担，以及随着人口老龄化中风的咆哮流行，我们的建议是及时的。此外，由于西奈山服务的是一个三种族社区，少数族裔中风的比例不成比例，它准备吸引对推动少数族裔中风医疗保健问题感兴趣的少数族裔申请者。在脑血管计划和神经保护计划的广度和深度范围内，博士后实习生(医学博士和/或博士)将获得一个出色的、单独指导的环境(10名由NIH资助的导师)，在那里他们可以沉浸在基础/教学课程工作中，包括儿科脑血管疾病、实验设计和方法学以及其他关键应用于主要基础或临床研究研究领域的研究技术(如拨款撰写、道德行为)。博士后实习生将受到密切的监督和指导，以便能够通过结构化、互动的环境过渡到独立的、基础的或临床神经科学家。重点是独立研究，展示思考、批判性推理、科学写作、演示和协作的技能。通过积极的招聘战略，包括关注少数族裔申请者，研究员将接受为期2-3年的培训。我们预计将招聘具有研究经验但对脑血管疾病/神经保护/细胞死亡知之甚少的博士，以及寻求高强度、高水平的面向翻译的研究培训的医学博士(受过临床培训的神经学家、神经外科医生和急诊内科医生)，以使他们能够作为未来的研究人员成功竞争。我们还将招募医学博士，准备将他们的综合技能集中在一种特定的、常见的和致残的神经疾病上。该项目将由莱文博士(主任)管理，他是一位经验丰富、成功的导师和研究人员，也是一个精心挑选的执行委员会。我们将提供培训和经验，以及一个定制的咨询委员会，允许博士后研究员在完成我们的项目后成为独立和成功的研究人员。由于中风是美国第三大死亡原因和成人残疾的第一大原因，中风仍然是当今美国的主要公共卫生问题之一。尽管如此，加上美国人口老龄化，美国政府指定的中风研究培训项目寥寥无几。我们的建议将增加一个中风培训计划，该计划将专注于培养下一代中风研究人员，通过在卓越的研究和培训环境中通过几种临床和基础研究途径来解决中风问题。

DESCRIPTION (provided by applicant): This proposal is for a new highly focused postdoctoral training program in cerebrovascular disease that will be based in the Departments of Neurology, Neurosurgery, Neuroscience, and Emergency Medicine at The Mount Sinai Schools of Medicine and Graduate School of Biological Sciences within the Mount Sinai Stroke and Medical Centers. Very strong interdepartmental and multi-disciplinary collaborations have been fostered and solidified, and extramural funding from the NIH has grown exponentially. Based on a fertile and expanding research presence with an established, active and competitive training component, we seek to formalize the research training and career development of the next generation of physician and research scientists in this arena of proven strength within these departments. We have taken multiple concrete steps to insure a cohesive program among the clinical and basic faculty mentors. Our proposal is timely given the tremendous burden of illness stroke causes and the growling epidemic of stroke as the population ages. Further, as Mount Sinai serves a tri-racial community, with minorities experiencing a disproportionate share of stroke, it is poised to attract minority applicants interested in advancing minority health-care issues in stroke. Within the breadth and depth of the cerebrovascular program and the neuroprotection programs, postdoctoral trainees (M.D.s and/or Ph.D.s) will be given an outstanding mentored, individually crafted milieu (10 NIH-funded mentors) where they can immerse in basic/didactic course work, including pediatric cerebrovascular disease, experimental design and methodology and other research techniques (e.g. grant writing, ethical conduct) critically applied to either primarily basic or clinical investigative areas of research. Postdoctoral trainees will be closely supervised and mentored to be able to transition to an independent, basic or clinical neuroscientist through a structured, interactive environment. The focus is on independent research, demonstrating skills of thought, critical reasoning, scientific writing, and presentations, and collaboration. With active recruiting strategies, including attention to minority applicants, fellows will train for a period of 2-3 years. We anticipate recruiting Ph.D.s with research experience but with limited knowledge of cerebrovascular diseases/neuroprotection/cell death, and M.D.s (clinically trained neurologists, neurosurgeons, and emergency medicine physicians) seeking intensive, high-level translational-oriented research training allowing them to compete successfully as future investigators. We will also recruit M.D.-Ph.D.s ready to focus their combined skills towards a specific common, and disabling neurological disease. The program will be administered by Dr. Levine (Director), an experienced and successful mentor and researcher and a carefully chosen Executive Committee. We will provide the training and experience and a customized Advisory Committee that will allow postdoctoral fellows to become independent and successful investigators upon completion of our program. As stroke is the third leading cause of death in America and the number one cause of adult disability, stroke remains one of the major public health problems in the United States today. Despite this, and the aging population of America, there are very few government-designated training programs in stroke research in the country. Our proposal would add a stroke training program that will focus on preparing the next generation of stroke researchers to tackle the problem of stroke via several avenues of clinical and basic research within an outstanding research and training environment.