NALTREXONE HCL TO DECREASE INCIDENCE & SEVERITY OF SELF-INJURY IN MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 很少有药物干预实验室灵长类动物的自伤行为（SIB）进行了彻底的评价。 作为正在进行的纳洛酮HC（以10 mg/ml的浓度配制成可口的糖浆）长期评价的一部分，迄今为止已记录了12只笼中亚成体和成年雄性恒河猴的行为数据和创伤发生率。 此外，受伤的发生率和严重程度被用作唯一的因变量，用于评估另外5名很少或从不表现出自咬行为的男性受试者的这种干预。 在开始给药前和整个研究期间定期进行体格检查、全血细胞计数、血生化、尿分析和行为观察，共计153小时。 动物每24小时经口给药一次，剂量为3.2 mg/kg。 对个体进行重新评估，每2 - 4周逐渐增加给药间隔，最长间隔为96小时。 在治疗的第一周内，观察到几名受试者的自咬频率显著降低。 在行为研究的所有受试者中，每日和每隔一天给药的自咬率均显著降低。 回合次数较少，回合长度不受影响。纳洛酮没有改变其他行为的水平，表明药物没有全身或镇静作用。 在所有研究对象中，自伤的发生率明显较低。 结果表明，饲养背景的可能影响，最显着的改善被认为是在动物的母亲饲养的社会环境。 环境，而不是内源性的触发器可能更普遍的托儿所饲养和社会剥夺的猕猴。 继续的研究将评估这种可能性，以及其他剂量水平和长期疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Few pharmacological interventions for self-injurious behavior (SIB) in laboratory primates have been thoroughly evaluated. As part of an ongoing long-term evaluation of naltrexone HC (compounded into a palatable syrup at 10mg/ml), behavioral data and incidence of wounding has been recorded for 12 caged subadult and adult male rhesus macaques to date. In addition, the incidence and severity of wounding is being used as sole dependent variables for assessing this intervention in an additional five male subjects that rarely or never display self-biting behavior. Physical exams, complete blood counts, blood chemistry, urinalysis, and behavioral observation totaling 153 h were performed before beginning treatment and at regular intervals throughout the duration of the study. Animals were dosed at 3.2mg/kg orally once every 24 hours. Individuals were reassessed and dosing intervals were gradually increased every two to four weeks, with a maximum interval of 96 hours. Dramatic reductions in the frequency of self-biting were observed within the first week of treatment for several subjects. Over all subjects studied behaviorally, rates of self-biting were significantly lower with both the daily and every-other-day dosing. Bouts were less frequent, and bout length was unaffected. Naltrexone did not alter levels of other behaviors, indicating no generalized or sedating effect of the medication. Incidence of self-wounding was markedly lower among all subjects studied. Results suggest a possible influence of rearing background; the most dramatic improvements were seen in animals mother-reared in a social setting. Environmental as opposed to endogenous triggers may be more prevalent in nursery-reared and socially-deprived macaques. Continued research will evaluate this possibility, as well as other dosing levels and long-term efficacy.