ABNORMAL BEHAVIOR & ONSET OF INITIAL SOCIALIZATION AMONG RHESUS MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 托儿所饲养的猕猴的社会化通常涉及大约一个月大的初始社会接触。 然而，在生物医学环境中，由于各种原因，社会化的开始可能会延迟。 这项正在进行的研究检查了预测，这些延迟与不成熟的，社会化饲养的恒河猴中异常行为的广泛表达有关。 为了控制所经历的研究程序的类型和延迟社会化的原因，所有受试者都来自一个对早期社会化施加限制的研究项目。 受试者包括35名女性和33名男性，第一次社交年龄在1至54个月之间。 每年对每个受试者进行三次五分钟的调查，记录16种异常行为的存在。 每个主题的数据收集时间长达四年。 通过简单的回归程序确定每个队列中社会化年龄和异常行为频率之间的关系。 在社会化的发病年龄的影响是显而易见的，在第二和第三年的生活，发病的社会化是呈正相关的异常行为剧目的宽度。 目前在年龄较大的青少年中未观察到较长期的影响。 初步结果表明，有关早期社会化的决定需要在延迟社会化的理由和促进正常发展之间取得谨慎的平衡。 继续的研究将允许对许多现有的受试者进行持续的纵向检查，因为他们成熟为成年人，以测量这些影响在大样本量的受试者中的持续性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The socialization of nursery-reared macaques typically involves initial social exposure at approximately one month of age. However, in a biomedical environment, the onset of socialization may be delayed for a variety of reasons. This ongoing study examined the prediction that these delays are associated with broadened expression of abnormal behaviors among immature, socially-housed rhesus macaques. In order to control for the types of research procedures experienced and the reason for delayed socialization, all subjects were drawn from one research project that imposed restrictions on early socialization. Subjects included 35 female and 33 males first socialized between one and 54 months of age. Three five-minute surveys were conducted on each subject annually, recording the presence of 16 abnormal behaviors. Data have been collected on each subject for up to four years. Associations between age at socialization and frequency of abnormal behavior within each cohort were determined by simple regression procedures. Effects of age at onset of socialization are apparent in the second and third year of life; onset of socialization was positively related to breadth of the abnormal behavior repertoire. Longer term effects are currently not observed among older adolescents. Initial results suggest that decisions regarding early socialization need to strike a careful balance between the rationale for delayed socialization and the promotion of normal development. Continued research will permit continued longitudinal examination of many existing subjects as they mature into adults to measure the persistence of these effects among a large sample size of subjects.