Identification of a new thrombosis mechanism triggered by dying platelets

鉴定死亡血小板引发的新血栓形成机制

• 批准号: nhmrc : 1127278
• 负责人: Prof Shaun Jackson
• 金额: $ 41.54万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-new-thrombosis-dying-platelets/947974
• 关键词: Identification; new; thrombosis; mechanism; triggered

A severe reduction in blood flow (ischemia) to the intestines can trigger blood clot formation (thrombosis) in multiple organs, including the lungs. We have identified a new thrombosis mechanism that is triggered by the clumping of white blood cells in the intestines, leading to widespread thrombosis in the lung. Here we will investigate the mechanisms triggering this thrombosis mechanism with the ultimate aim of identifying more effective antithrombotic approaches.

流向肠道的血流量严重减少(缺血)会引发多个器官的血液凝块形成(血栓形成)，包括肺部。我们已经确定了一种新的血栓形成机制，这种机制是由肠道中的白细胞聚集触发的，导致肺内广泛的血栓形成。在这里，我们将研究触发这种血栓形成机制的机制，最终目的是确定更有效的抗血栓方法。