Investigation of a New Leukocyte Recruitment Mechanism at Sites of Vascular Injury

血管损伤部位新的白细胞招募机制的研究

• 批准号: nhmrc : 1028564
• 负责人: Prof Shaun Jackson
• 金额: $ 36.49万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-new-leukocyte-vascular-injury/110648
• 关键词: Investigation; New; Leukocyte; Recruitment; Mechanism

Blood clots formed at sites of small vessel injury can cause damage of vital organs by obstructing blood flow and promoting a proinflammatory response by efficiently recruiting and activating leukocytes. The molecular mechanisms responsible for the latter event are poorly defined. We have established a new mouse model, gained novel insights into the leukocyte recruitment by blood clots, and aim to define the precise mechanism for this process in this application.

在小血管损伤部位形成的血凝块会阻碍血流，并通过有效地招募和激活白细胞促进促炎反应，从而对重要器官造成损害。导致后一事件的分子机制尚不明确。我们建立了一种新的小鼠模型，对血凝块的白细胞募集有了新的认识，并旨在确定这一过程的精确机制。