Investigation of a New Leukocyte Recruitment Mechanism at Sites of Vascular Injury
Investigation of a New Leukocyte Recruitment Mechanism at Sites of Vascular Injury
批准号:
nhmrc : 1028564
负责人:
Prof Shaun Jackson
金额:
$36.49万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
在小血管损伤部位形成的血块可以阻碍血液流动,并通过有效地招募和激活白细胞来促进促炎反应,从而导致重要器官的损害。负责后一种事件的分子机制还不清楚。我们已经建立了一个新的小鼠模型,对血液凝块对白细胞的募集有了新的见解,目的是在这一应用中定义这一过程的精确机制。
英文摘要
Blood clots formed at sites of small vessel injury can cause damage of vital organs by obstructing blood flow and promoting a proinflammatory response by efficiently recruiting and activating leukocytes. The molecular mechanisms responsible for the latter event are poorly defined. We have established a new mouse model, gained novel insights into the leukocyte recruitment by blood clots, and aim to define the precise mechanism for this process in this application.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Identification of a new thrombosis mechanism triggered by dying platelets
-
批准号:nhmrc : 1127278
-
项目类别:Project Grants
-
资助金额:$41.54万
-
财政年份:2017
-
负责人:Prof Shaun Jackson
-
依托单位:
Identification of a new thrombosis mechanism triggered by dying platelets
-
批准号:nhmrc : GNT1127278
-
项目类别:Project Grants
-
资助金额:$60.87万
-
财政年份:2017
-
负责人:Prof Shaun Jackson
-
依托单位:
Intravascular leukocyte trafficking during thromboinflammation
-
批准号:nhmrc : 1127267
-
项目类别:Project Grants
-
资助金额:$45.64万
-
财政年份:2017
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigating a potential new treatment for stroke
-
批准号:nhmrc : 1079400
-
项目类别:Research Fellowships
-
资助金额:$58.58万
-
财政年份:2015
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigating a potential new treatment for stroke
-
批准号:nhmrc : GNT1079400
-
项目类别:Research Fellowships
-
资助金额:$83.69万
-
财政年份:2015
-
负责人:Prof Shaun Jackson
-
依托单位:
Identification of a novel adhesion mechanism regulating platelet-endothelial interactions.
-
批准号:nhmrc : 1066957
-
项目类别:Project Grants
-
资助金额:$33.45万
-
财政年份:2014
-
负责人:Prof Shaun Jackson
-
依托单位:
Development of an ultra-high speed spinning disk confocal micro-particle image velocimetry (PIV) platform for the investigation of cardiovascular disease
-
批准号:LE120100043
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$22.0万
-
财政年份:2014
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of the proinflammatory function of platelets during ischaemia-reperfusion injury
-
批准号:nhmrc : 1048574
-
项目类别:Project Grants
-
资助金额:$36.86万
-
财政年份:2013
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of a novel mechanism causing platelet hyperactivity in diabetes
-
批准号:nhmrc : 1042886
-
项目类别:Project Grants
-
资助金额:$38.88万
-
财政年份:2013
-
负责人:Prof Shaun Jackson
-
依托单位:
Australia Fellowship
-
批准号:nhmrc : 606718
-
项目类别:NHMRC Research Fellowships
-
资助金额:$266.72万
-
财政年份:2010
-
负责人:Prof Shaun Jackson
-
依托单位:
Development of Model Systems to Investigate Blood Hydrodynamic Parameters Affecting Blood Cell Function: An Interdisciplinary Approach
-
批准号:DP0987643
-
项目类别:Discovery Projects
-
资助金额:$20.72万
-
财政年份:2009
-
负责人:Prof Shaun Jackson
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 545953
-
项目类别:NHMRC Research Fellowships
-
资助金额:$12.82万
-
财政年份:2009
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of the role for GPVI in platelet function and thrombosis
-
批准号:nhmrc : 491166
-
项目类别:NHMRC Project Grants
-
资助金额:$36.19万
-
财政年份:2008
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigate novel functional roles for PI 3-kinases in platelets.
-
批准号:nhmrc : 491165
-
项目类别:NHMRC Project Grants
-
资助金额:$35.82万
-
财政年份:2008
-
负责人:Prof Shaun Jackson
-
依托单位:
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System
-
批准号:DP0663904
-
项目类别:Discovery Projects
-
资助金额:$20.34万
-
财政年份:2006
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigate the role of PAF and CD40 ligand in regulating the proinflammatory properties of platelets
-
批准号:nhmrc : 384249
-
项目类别:NHMRC Project Grants
-
资助金额:$33.82万
-
财政年份:2006
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of a novel role for Factor XIII in regulating the adhesive function of platelets
-
批准号:nhmrc : 334080
-
项目类别:NHMRC Project Grants
-
资助金额:$16.2万
-
财政年份:2005
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of mechanotransduction mechanisms in platelets
-
批准号:nhmrc : 284266
-
项目类别:NHMRC Project Grants
-
资助金额:$32.11万
-
财政年份:2004
-
负责人:Prof Shaun Jackson
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 284267
-
项目类别:NHMRC Research Fellowships
-
资助金额:$47.59万
-
财政年份:2004
-
负责人:Prof Shaun Jackson
-
依托单位:
Investigation of Activating signals Transmitted during Platelet Aggregation
-
批准号:nhmrc : 237011
-
项目类别:NHMRC Project Grants
-
资助金额:$17.85万
-
财政年份:2003
-
负责人:Prof Shaun Jackson
-
依托单位:
海外基金