Investigation of a New Leukocyte Recruitment Mechanism at Sites of Vascular Injury

血管损伤部位新的白细胞招募机制的研究

• 批准号: nhmrc : 1028564
• 负责人: Prof Shaun Jackson
• 金额: $ 36.49万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-new-leukocyte-vascular-injury/110648
• 关键词: Investigation; New; Leukocyte; Recruitment; Mechanism

Blood clots formed at sites of small vessel injury can cause damage of vital organs by obstructing blood flow and promoting a proinflammatory response by efficiently recruiting and activating leukocytes. The molecular mechanisms responsible for the latter event are poorly defined. We have established a new mouse model, gained novel insights into the leukocyte recruitment by blood clots, and aim to define the precise mechanism for this process in this application.

小血管损伤部位形成的血凝块可通过阻碍血流并通过有效募集和激活白细胞促进促炎反应而导致重要器官损伤。导致后一事件的分子机制尚不清楚。我们建立了一种新的小鼠模型，获得了对血凝块招募白细胞的新见解，并旨在在此应用中确定该过程的精确机制。