Identification of a novel adhesion mechanism regulating platelet-endothelial interactions.

鉴定调节血小板-内皮相互作用的新型粘附机制。

• 批准号: nhmrc : 1066957
• 负责人: Prof Shaun Jackson
• 金额: $ 33.45万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-adhesion-endothelial-interactions/455272
• 关键词: Identification; novel; adhesion; mechanism; regulating

Platelets are important blood cells, stopping bleeding in the event of blood vessel injury. However, platelets can also interact with the blood vessel lining (endothelium) to regulate and in some cases promote inflammation. We have identified a new structure platelets use to stick to endothelium, which under disease states (enhanced oxidative stress), can promote inflammation. We will investigate how tractopods form, and examine their role in the setting of elevated oxidative stress and inflammatory disease.

血小板是重要的血细胞，在血管受伤时可以止血。然而，血小板也可以与血管内膜（内皮）相互作用，调节并在某些情况下促进炎症。我们已经确定了血小板粘附内皮的一种新结构，这种结构在疾病状态下（增强氧化应激）可以促进炎症。我们将研究tractopods是如何形成的，并研究它们在氧化应激升高和炎症性疾病中的作用。