Intravascular leukocyte trafficking during thromboinflammation

血栓炎症期间血管内白细胞运输

• 批准号: nhmrc : 1127267
• 负责人: Prof Shaun Jackson
• 金额: $ 45.64万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intravascular-leukocyte-trafficking-thromboinflammation/947971
• 关键词: Intravascular; leukocyte; trafficking; during; thromboinflammation

Unblocking blood vessels to treat heart attack and stroke can unfortunately cause a paradoxical worsening of organ damage, due to increased inflammation upon blood flow restoration. We have identified a novel way in which this side-effect is regulated by the small blood clotting cells platelets, and the protein fibrin. We will investigate ways to reduce the pro-inflammatory role for platelets, and define safer clot busting treatments.

不幸的是，疏通血管以治疗心脏病发作和中风可能会导致器官损伤的矛盾恶化，这是因为血流恢复时炎症增加。我们已经确定了一种新的方式，通过小的血液凝结细胞、血小板和蛋白质纤维蛋白来调节这种副作用。我们将研究减少血小板的促炎作用的方法，并确定更安全的血栓破裂治疗方法。