Investigation of the proinflammatory function of platelets during ischaemia-reperfusion injury

缺血再灌注损伤过程中血小板促炎功能的研究

• 批准号: nhmrc : 1048574
• 负责人: Prof Shaun Jackson
• 金额: $ 36.86万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-proinflammatory-function-reperfusion-injury/112024
• 关键词: Investigation; proinflammatory; function; platelets; during

Platelets are important blood cells that stop bleeding. Platelets also regulate inflammation by modulating the function of white blood cells. Excessive stimulation of white cells by platelets may cause tissue damage relevant to a broad of cardiovascular diseases, including heart disease and stroke. This grant application aims to investigate the precise mechanism by which platelets promote inflammation during a heart attack or stroke.

血小板是止血的重要血细胞。血小板还通过调节白色血细胞的功能来调节炎症。血小板对白色细胞的过度刺激可能导致与广泛的心血管疾病相关的组织损伤，包括心脏病和中风。这项拨款申请旨在研究血小板在心脏病发作或中风期间促进炎症的确切机制。