Investigating a potential new treatment for stroke

研究中风的潜在新疗法

• 批准号: nhmrc : 1079400
• 负责人: Prof Shaun Jackson
• 金额: $ 58.58万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-potential-new-treatment-stroke/518661
• 关键词: Investigating; potential; new; treatment; stroke

Blood clots blocking blood flow to the brain (stroke) are a major cause of death and disability. Safety concerns limit approved therapies to a small subset of patients, highlighting an urgent need for safer, more effective drugs. Our studies show that inhibitors of the enzyme PI3Kbeta increase blood clot permeability, increasing clot ‘dissolvability’, without increased bleeding. This raises the possibility that PI3Kbeta inhibitors may represent a safe and effective adjuvant therapy for stroke.

血块阻断流向大脑的血液（中风）是死亡和残疾的主要原因。安全问题将批准的疗法限制在一小部分患者中，强调迫切需要安全，更有效的药物。我们的研究表明，酶PI3KBETA的抑制剂会增加血凝块渗透性，增加凝块的“溶解性”，而不会增加出血。这增加了PI3KBETA抑制剂可能代表中风的安全有效辅助治疗的可能性。