Investigation of a novel mechanism causing platelet hyperactivity in diabetes

糖尿病血小板过度活跃的新机制研究

• 批准号: nhmrc : 1042886
• 负责人: Prof Shaun Jackson
• 金额: $ 38.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-novel-mechanism-hyperactivity-diabetes/111522
• 关键词: Investigation; novel; mechanism; causing; platelet

Diabetes represents a serious global health crisis, set to explode over the next few decades. A large proportion of deaths associated with Diabetes can be attributed to a high incidence of cardiovascular disease, with diabetic platelets shown to be ‘hyperactive’. We have defined a novel pathway sensitive to the shear forces of blood flow, which leads to platelet hyperactivity in diabetics. We will investigate potential ways to dampen this pathway, which may offer promise as novel treatments for diabetic patients.

糖尿病是一种严重的全球健康危机，将在未来几十年内爆发。与糖尿病相关的大部分死亡可归因于心血管疾病的高发病率，糖尿病患者的血小板显示为“过度活跃”。我们已经确定了一个新的途径敏感的剪切力的血流，导致血小板过度活跃的糖尿病患者。我们将研究抑制这一途径的潜在方法，这可能为糖尿病患者提供新的治疗方法。