Investigation of a novel mechanism causing platelet hyperactivity in diabetes

糖尿病血小板过度活跃的新机制研究

• 批准号: nhmrc : 1042886
• 负责人: Prof Shaun Jackson
• 金额: $ 38.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-novel-mechanism-hyperactivity-diabetes/111522
• 关键词: Investigation; novel; mechanism; causing; platelet

Diabetes represents a serious global health crisis, set to explode over the next few decades. A large proportion of deaths associated with Diabetes can be attributed to a high incidence of cardiovascular disease, with diabetic platelets shown to be ‘hyperactive’. We have defined a novel pathway sensitive to the shear forces of blood flow, which leads to platelet hyperactivity in diabetics. We will investigate potential ways to dampen this pathway, which may offer promise as novel treatments for diabetic patients.

糖尿病代表着严重的全球健康危机，将在接下来的几十年中探索。与糖尿病相关的大部分死亡可能归因于大量的心血管疾病，糖尿病血小板显示为“过度活跃”。我们定义了一种对血流剪切力敏感的新途径，这导致糖尿病患者的血小板多动症。我们将研究该途径的潜在方法，这可能会为糖尿病患者提供新的治疗方法。