Investigating a potential new treatment for stroke

研究中风的潜在新疗法

• 批准号: nhmrc : GNT1079400
• 负责人: Prof Shaun Jackson
• 金额: $ 83.69万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-potential-new-treatment-stroke/1345280
• 关键词: Investigating; potential; new; treatment; stroke

Blood clots blocking blood flow to the brain (stroke) are a major cause of death and disability. Safety concerns limit approved therapies to a small subset of patients, highlighting an urgent need for safer, more effective drugs. Our studies show that inhibitors of the enzyme PI3Kbeta increase blood clot permeability, increasing clot ‘dissolvability’, without increased bleeding. This raises the possibility that PI3Kbeta inhibitors may represent a safe and effective adjuvant therapy for stroke.

血栓阻塞血液流向大脑（中风）是死亡和残疾的主要原因。安全性问题将批准的治疗限制在一小部分患者中，突出了对更安全，更有效药物的迫切需求。我们的研究表明，酶PI3K β的抑制剂增加血凝块的渗透性，增加凝块的“溶解性”，而不增加出血。这增加了PI3K β抑制剂可能代表中风的安全有效的辅助治疗的可能性。