Investigating Obesity and Chronic Disease-Related Risk Factors of Alaska Natives

调查阿拉斯加原住民的肥胖和慢性病相关危险因素

• 批准号: 7651093
• 负责人: BERT Brandon BOYER
• 金额: $ 175.38万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7651093
• 关键词: Investigating; Obesity; Chronic; Disease; Related

DESCRIPTION (provided by applicant): The overall goal of the proposed COBRE-funded Center for Alaska Native Health Research (CANHR) is to achieve a permanent and sustainable research center at the University of Alaska Fairbanks (UAF) with the primary theme of investigating obesity and chronic disease-related risk, control, and prevention among Alaska Natives. Specific Aim 1. To enhance the biomedical research infrastructure for Alaska Native health research at the University of Alaska. This will be achieved through an increase in the University's commitment to biomedical research with Alaska Natives, additional research opportunities through an expansion of the number of Alaska Native research sites, formation of statewide research partnerships; and strengthening the integrated organizational structure for COBRE II research. Standing cores have been strengthened and functions consolidated; a Nutrition and Physical Activity Core has been added. The cores are aligned with the long-term CANHR research agenda. Specific Aim 2. Increase the number of investigators at the University of Alaska receiving NIH independent investigator funding for CANHR-related research. This will be achieved by completing four research projects by highly talented new CANHR investigators. Investigators are pursuing research that 1) develops a cultural understanding of the perceptions of weight and diabetes etiology and their relationships to health among Yup'ik Eskimos; 2) investigates a methodology of unbiased biomarkers of dietary intake based on variations in food stable isotope ratios and compares those biomarkers to concurrent diet records; 3) determines nutrients and contaminants in Yup'ik subsistence food sources; and 4) understands more precisely and measures stressors and coping methods among Yup'ik Eskimos. Each investigation will provide a more differentiated understanding of health disparities of Alaska Natives. They will serve as the basis for applications to NIH and a foundation for prevention, applied, and basic research into Alaska Native health disparities. CANHR will increase capacity and strengthen its mentorship ability by hiring two Associate Professors with a record of success in NIH funding. CANHR contributes to the public health of the Alaskan population by identifying risk and protective factors for chronic diseases among an underserved population. Results have implications for understanding the causes and contributing factors of health disparities of other rural minorities in America and in the circumpolar North. They have the potential for translation into additional research that will develop evidence-based practices for primary and secondary prevention. The COBRE provides a foundation for sustaining a research environment with a mission of utilizing research to influence policy and practices that can reduce health disparities.

描述（由申请人提供）：拟议的cobre资助的阿拉斯加土著健康研究中心（CANHR）的总体目标是在阿拉斯加费尔班克斯大学（UAF）建立一个永久性和可持续的研究中心，其主要主题是调查阿拉斯加土著人的肥胖和慢性疾病相关的风险、控制和预防。具体目标加强阿拉斯加大学阿拉斯加原住民健康研究的生物医学研究基础设施。这将通过增加大学对阿拉斯加原住民生物医学研究的承诺，通过扩大阿拉斯加原住民研究地点的数量增加研究机会，形成全州范围的研究伙伴关系来实现；加强COBRE II研究的整合组织结构。常备核心得到加强，功能得到巩固；增加了营养和体力活动核心。这些核心与CANHR的长期研究议程保持一致。具体目标2。增加阿拉斯加大学接受美国国立卫生研究院独立研究者资助的canhr相关研究的研究人员数量。这将通过由才华横溢的新CANHR调查员完成四个研究项目来实现。调查人员正在进行的研究是：1)在爱斯基摩人中发展对体重和糖尿病病因的认知及其与健康的关系的文化理解；2)研究了一种基于食物稳定同位素比值变化的无偏膳食摄入生物标志物的方法，并将这些生物标志物与同期饮食记录进行了比较；3)确定雅卜克族自给食物来源中的营养物质和污染物；4)更准确地了解和测量爱斯基摩人的压力源和应对方法。每项调查都将对阿拉斯加土著人的健康差异提供更有区别的理解。它们将作为向美国国立卫生研究院申请的基础，并为阿拉斯加原住民健康差异的预防、应用和基础研究奠定基础。CANHR将通过雇用两位在NIH资助方面有成功记录的副教授来提高能力并加强其指导能力。CANHR通过确定服务不足人口中慢性病的风险和保护因素，为阿拉斯加人口的公共健康作出贡献。研究结果对理解美国和环北极地区其他农村少数民族健康差异的原因和影响因素具有启示意义。它们有可能转化为进一步的研究，从而为一级和二级预防制定基于证据的做法。COBRE为维持研究环境奠定了基础，其使命是利用研究影响能够减少健康差距的政策和做法。