SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

SC COBRE 针对发育性心血管疾病

• 批准号: 7651098
• 负责人: ROGER R MARKWALD
• 金额: $ 207.69万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7651098
• 关键词: SC; COBRE; DEVELOPMENTALLY; BASED; CARDIOVASCULAR

DESCRIPTION (provided by applicant): Commitment to mentorship, strong external review, solid Core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented junior investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, Core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.

描述（由申请人提供）：对指导的承诺、强有力的外部审查、坚实的核心实验室支持、有凝聚力的主题以及对有价值候选人的选择标志着南卡罗来纳医科大学和南卡罗来纳大学对 COBRE 在心血管发育和疾病方面的最初 5 年的支持。我们的 9 名目标教师中的 6 名的职业发展记录、153 篇发表的期刊文章、书籍和摘要以及 COBRE 参与者的 121 次演讲都记录了我们的成功。 COBRE 资金还直接促进了 9 名教师的招聘，特别是其中包括一名少数族裔科学家。 COBRE 联合机构基金对项目开发的支持（以种子资助的形式）为另外 7 名初级教员研究人员提供了关键资源。此次更新利用了原始项目的优势，实现了更具挑战性的目标——在心血管发育生物学的科学主题内建立竞争性项目拨款申请，我们将其定义为（1）正常和异常发育的机制，（2）成人心血管疾病的发育基础和（3）应用发育生物学（再生医学）。超过 11,000 平方英尺实验室空间专用于我们的 COBRE 赞助中心心血管发育生物学中心 (CDBC)。我们已经确定了四名才华横溢的初级研究员作为本次更新申请的目标教师，并描述了招募第五名的计划。分配给我们的 COBRE 中心的捐赠主席将有可能招募一位杰出的高级科学家来提供额外的科学领导和计划开发。我们的更新计划继续强调初始资助期的成功策略，并增加计划要素，以加强目标教员、高级科学研究人员、核心实验室主任和临床医生（特别是儿科心脏病学）之间的富有成效的合作。 MUSC 和 COBRE 支持的心血管发育生物学和再生医学研究的结合是独特的，本质上是转化性的；我们相信这将为其他机构提供一个范例。该提案描述了为开发 PPG 和 SCCOR 应用程序建立有效的科学团队合作的计划，这些计划将在 P20 资助周期之外维持 CDBC，同时加强我们机构和全国的心血管发育和再生医学科学界。