CONFOCAL DIFFRACTION PHASE MICROSCOPY OF LIVE CELLS

活细胞的共焦衍射相位显微镜

• 批准号: 7955869
• 负责人: WOO-BAEG CHOI
• 金额: $ 1.9万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955869
• 关键词: Biomedical Research; Cells; Computer Retrieval of Information on Scientific Projects Database; Confocal Microscopy; Funding; Grant; Institution; Interferometry; Lasers; Length; Life; Measurement; Measures; Microscopy; Optics; Phase; Refractive Indices; Research; Research Personnel; Resources; Sampling; Site; Source; Specimen; Techniques; Thick; United States National Institutes of Health; bioimaging; nanoscale; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Confocal microscopy is a well established, powerful technique for biomedical imaging mainly because of its ability to provide optical sectioning in relatively thick specimens. Confocal diffraction phase microscopy is a new quantitative phase microscopy technique that provides quantitative phase measurements from localized sites on a sample with high sensitivity. The technique combines common-path interferometry with confocal microscopy in a transmission geometry and can be used for measuring both the optical path-length and refractive index of a transparent sample and quantifying the nanometer scale fluctuations.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 共聚焦显微镜是一种成熟的、功能强大的生物医学成像技术，主要是因为它能够在相对较厚的标本中提供光学切片。共焦衍射相位显微术是一种新的定量相位显微术，它可以从样品上的局部位置提供高灵敏度的定量相位测量。该技术结合了共光路干涉与共焦显微镜的传输几何形状，可用于测量光程长度和透明样品的折射率和量化纳米尺度的波动。