ODT MONITORING INTRATUMORAL BLOOD FLOW DURING PHOTODYNAMIC THERAPY(PDT)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议研究的目标有两个方面：（1）与传统组织学检查相比，获得关于ODT作为人类皮肤癌诊断手段的能力的数据;（2）在光动力治疗（PDT）期间实时监测肿瘤内血流。 给予足够剂量的光，在适当的波长，含有光敏剂的组织是必不可少的PDT。 因此，监测光动力治疗过程中光传递在组织中的作用具有重要的临床意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of the proposed research will be two-fold (1) obtain data on the ability of ODT as a means of diagnosis of human skin cancer, as compared to conventional histologic examination; and (2) monitor intratumoral blood flow in real-time during Photodynamic Therapy (PDT). The administration of a sufficient dose of light, at the appropriate wavelength, to photosensitizer-containing tissue is essential for PDT. Accordingly, monitoring the effects of light delivery in tissue during PDT has great clinical significance.