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Descriptive Studies and Record Linkage

描述性研究和记录链接

基本信息

批准号：
7966681
负责人：
William Anderson
金额：
$ 179.34万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7966681
关键词：
Adenoid Cystic Carcinoma Adult Affect Age Age-Years Ambulatory Care Facilities Anatomic Sites Anus Area Asians Atlas of Cancer Mortality in the United States Autoimmune Diseases B-Lymphocytes Biological Biology Birth Breast Cancer Risk Factor Burkitt Lymphoma Calendar Cancer Etiology Cancer Surveillance Research Catchment Area Categories Caucasoid Race Characteristics Childhood Childhood Burkitt&apos s Lymphoma Classification Clinical Cohort Effect Colorectal Cancer Communicable Diseases Computer software Cutaneous Cutaneous Lymphoma Data Data Analyses Data Linkages Databases Descriptive Epidemiology Detection Diagnostic Diagnostic Procedure Disease Disease susceptibility Division of Cancer Epidemiology and Genetics Early Diagnosis Elderly Endometrial Carcinoma Epithelial ovarian cancer Esophageal Squamous Cell Carcinoma Estrogen receptor positive Ethnic group Evaluation Family Female Female Breast Carcinoma Female breast Female genitalia Formalin Future Gallbladder Gender Hawaii Head and Neck Cancer Head and neck structure Heterogeneity Hispanics Histologic Hospitalization Incidence Inflammatory Inpatients Institutes Iowa Kaposi Sarcoma Laboratories Lip Cancer Lymphoma Male Genital Organs Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of esophagus Malignant neoplasm of lung Malignant neoplasm of male breast Malignant neoplasm of ovary Malignant neoplasm of thyroid Malignant neoplasm of urinary bladder Mammary Neoplasms Maps Medical Medical Surveillance Military Personnel Modeling Monoclonal gammopathy of uncertain significance Morphologic artifacts Multiple Myeloma National Cancer Institute Neuroblastoma Nodal Not Hispanic or Latino Occupational Exposure Papillary thyroid carcinoma Paraffin Embedding Pathologic Patients Pattern Peritoneum Plasmacytoma Population Postmenopause Premenopause Prevention Publishing Race Renal carcinoma Research Research Personnel Residual state Risk Risk Factors Role SEER Program Site Staging Stomach Carcinoma Subgroup Survival Rate T-Lymphocyte Thyroid Gland Time Tissue Microarray Tissues United States United States Department of Veterans Affairs Update Variant Weight Woman age group age related aged cancer risk cell type child bearing cohort early childhood geographic difference improved leukemia/lymphoma lifestyle factors male malignant breast neoplasm malignant tonsil neoplasm melanoma men molecular marker mortality parity population based programs repository reproductive sex trend tumor tumor registry web site

项目摘要

General descriptive studies (00350): Analyses of SEER incidence data revealed that esophageal squamous cell carcinoma rates, highest among blacks, have been declining not only among blacks and whites but also Hispanics and Asians. Stomach carcinoma incidence patterns differed by histologic type, anatomic site, race, gender, and age, suggesting that etiologic heterogeneity should be pursued in future research. Cervical cancer rates by histologic type were found to vary considerably among six Asian ethnic groups, non-Hispanic whites and blacks, and Hispanics, suggesting that early detection and prevention efforts require targeted strategies. Our analysis of the rising thyroid cancer incidence rates, which had been attributed to heightened medical surveillance and the use of improved diagnostics, revealed that rates were increasing not only for localized stage and small tumors but also for large tumors and non-localized stage, suggesting that surveillance and diagnostic procedures cannot completely explain the trends and other possible explanations should be explored. Further analysis of the gender and age-specific thyroid papillary cancer incidence patterns confirmed the well-established excess among females overall and found that the female-to-male rate ratio declined quite consistently from more than five at ages 20-24 to about one at ages 80+, without a clear difference between the childbearing, premenopausal, or postmenopausal years. Cutaneous adenoid cystic carcinomas were found to be rare appendageal tumors that affect males and females equally, predominate on the face/head/neck, usually present at a localized stage, and are associated with favorable survival. Our analysis of cutaneous lymphoma incidence patterns found that 71% were T-cell and 29% were B-cell type, in contrast to nodal lymphomas, and the rates varied markedly by race and sex, supporting the notion that they represent distinct disease entities. The risk factors and co-factors for sporadic childhood Burkitt lymphoma in the United States are unknown, and we found that early childhood exposures, male sex, and white race may raise risk. Further analysis of the Burkitt lymphoma incidence rates over the entire age range revealed clear childhood and geriatric peaks among both males and females, corresponding to the endemic and sporadic patterns, and a distinct third peak among adult males. Plasmacytoma incidence rates overall and by site were compared with those for multiple myeloma, and variations in the patterns according to race, gender, and age suggested underlying differences in clinical detection, susceptibility, disease biology and/or etiologic heterogeneity. Our evaluation of sex disparities in cancer incidence found that the male-to-female rate ratio ranged from 29 for Kaposi sarcoma, to 7 for lip cancer, 4 for bladder cancer, and 3 for tonsil cancer; only 5 cancers had a higher incidence in females: breast, thyroid, gallbladder, anus, and peritoneum. Several chapters were prepared focusing on the descriptive epidemiology of head and neck cancers and esophageal cancer. Special descriptive studies (10348): It is widely recognized that breast cancer incidence rates overall are higher among White than Black women. However, it is not generally appreciated that age-specific incidence rates are higher for Black women aged <40 years and higher for White women aged >40 years. This so-called Black to White ethnic crossover has been well-described, not fully understood, and sometimes viewed as an artifact. We used data from the National Cancer Institutes SEER database to assess the validity of the Black to White ethnic crossover in the United States. The Black and White ethnic crossover was a robust feature in the SEER database. Amidst recent declines for female breast cancer, age-adjusted incidence rates may be increasing for male breast cancer in the United States (US) and elsewhere. However, age-adjusted temporal trends reflect an age-specific weighted average, which may be confounded with age-related biological and/or temporal effects (period and/or cohort). We, therefore, supplemented the descriptive epidemiology of male and female breast cancer with age-period-cohort (APC) models, simultaneously adjusted for age, calendar-period, and birth-cohort effects. Results showed that male and female breast cancers demonstrated similar secular trends but different age-related biology; i.e., relatively more late-onset, low grade and ER positive tumors among men than women. A large-scale population-based comparison of male and female breast cancers demonstrated three intriguing results. Age-specific incidence patterns showed that the biology of male breast cancer resembled the late-onset type of female breast cancer. Similar breast cancer incidence trends among men and women suggested that there are common breast cancer risk factors that affect both sexes, especially estrogen receptor positive breast cancer. Finally, breast cancer mortality and survival rates have improved significantly over time for male breast cancer, but progress has lagged behind for men compared to women. We examined the relationship between endometrial cancer risk and reproductive characteristics in a population-based cohort of 2,674,465 Swedish women, 20-72 years of age. Compared to uniparous women, nulliparous women had a significantly elevated endometrial cancer risk. Endometrial cancer risk decreased with increasing parity. SEER special studies (00316): In 2001, the SEER program supplemented three tumor registries (Iowa, LA, and Hawaii) to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEERs Residual Tissue Repository for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs). Our 2nd SEER Residual Tissue Project will assess the population-based estimates for ovarian epithelial cancers (OEC). We will build the arrays for ovarian cancer, following a systematic pathologic review of all available ovarian cancer cases, i.e., approximately 1600.br> Mortality Rate Generator Software (00390): The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, is available at http://www.nci.nih.gov/atlasplus. Users can create customized maps according to cancer, age groups, sex, and race. The website has been updated to include data through 2004. Maps have been generated incorporating the new data and are being scrutinized by DCEG researchers. Record Linkage Studies: Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580): A large study of medical risk factors for multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) in the Veterans Administration (VA) inpatient hospitalization database found increased risk associated with broad categories of autoimmune disorders, infectious diseases and inflammatory disorders.br> US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382): DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk. Comparison of incidence rates in the U.S. active military population with those in the population-based SEER program found that rates were significantly lower in the military population for colorectal cancer in white men, lung cancer in white and black men and white women, and cervical cancer in black women.

一般描述性研究（00350）： 对SEER发病率数据的分析显示，食管鳞状细胞癌的发病率在黑人中最高，不仅在黑人和白人中，而且在西班牙裔和亚洲人中也在下降。胃癌的发病模式因组织类型、解剖部位、种族、性别和年龄的不同而不同，提示在未来的研究中应进一步探讨病因异质性。宫颈癌的组织学类型在6个亚洲种族、非西班牙裔白人和黑人以及西班牙裔之间存在很大差异，这表明早期发现和预防工作需要有针对性的策略。我们对甲状腺癌发病率上升的分析表明，不仅局部期和小肿瘤的发病率在上升，而且大肿瘤和非局部期的发病率也在上升，这表明监测和诊断程序不能完全解释这种趋势，应该探索其他可能的解释。甲状腺癌发病率上升归因于医疗监测的加强和诊断技术的改进。对性别和年龄特异性甲状腺乳头状癌发病率模式的进一步分析证实了女性总体上的过度，并发现女性与男性的比率从20-24岁时的5多降至80岁以上时的1左右，在生育、绝经前或绝经后年份之间没有明显差异。皮肤腺样囊性癌是一种罕见的阑尾肿瘤，对男性和女性的影响相同，主要发生在面部/头部/颈部，通常出现在局部阶段，并且与良好的生存率相关。我们对皮肤淋巴瘤发病率模式的分析发现，与结性淋巴瘤相比，71%为t细胞型，29%为b细胞型，而且发病率因种族和性别而有显著差异，支持它们代表不同疾病实体的观点。美国散发性儿童伯基特淋巴瘤的危险因素和辅助因素尚不清楚，我们发现儿童早期暴露、男性和白人种族可能会增加风险。对整个年龄段伯基特淋巴瘤发病率的进一步分析显示，男性和女性在儿童期和老年期都有明显的高峰，与地方性和散发性模式相对应，成年男性中有明显的第三个高峰。浆细胞瘤的总体发病率和不同部位的发病率与多发性骨髓瘤的发病率进行了比较，根据种族、性别和年龄的模式变化表明，在临床检测、易感性、疾病生物学和/或病因异质性方面存在潜在差异。我们对癌症发病率性别差异的评估发现，卡波西肉瘤的男女发病率比为29，唇癌为7，膀胱癌为4，扁桃体癌为3；只有5种癌症在女性中发病率较高：乳腺癌、甲状腺癌、胆囊癌、肛门癌和腹膜癌。编写了几章，重点介绍了头颈癌和食管癌的描述性流行病学。 特殊描述性研究（10348）： 人们普遍认为白人妇女的乳腺癌发病率总体上高于黑人妇女。然而，人们普遍没有认识到，年龄<40岁的黑人妇女发病率更高，而年龄在50 - 40岁的白人妇女发病率更高。这种所谓的黑人与白人的种族交叉被很好地描述了，但没有被完全理解，有时被视为人为的。我们使用来自美国国家癌症研究所SEER数据库的数据来评估美国黑人与白人种族交叉的有效性。在SEER数据库中，黑人和白人的种族交叉是一个强大的特征。在最近女性乳腺癌发病率下降的同时，美国和其他地区男性乳腺癌的年龄调整发病率可能正在上升。然而，年龄调整的时间趋势反映了特定年龄的加权平均值，这可能与年龄相关的生物学和/或时间效应（时期和/或队列）相混淆。因此，我们用年龄-时期-队列（APC）模型补充了男性和女性乳腺癌的描述性流行病学，同时调整了年龄、日历-时期和出生-队列效应。结果表明，男性和女性乳腺癌表现出相似的长期趋势，但与年龄相关的生物学特征不同；也就是说，男性的晚发性、低级别和ER阳性肿瘤相对多于女性。一项针对男性和女性乳腺癌的大规模人群比较显示了三个有趣的结果。年龄特异性发病率模式表明，男性乳腺癌的生物学特征与晚发型女性乳腺癌相似。男性和女性之间相似的乳腺癌发病率趋势表明，存在影响两性的常见乳腺癌危险因素，尤其是雌激素受体阳性的乳腺癌。最后，随着时间的推移，男性乳腺癌的死亡率和存活率有了显著改善，但与女性相比，男性的进展落后于女性。我们研究了子宫内膜癌风险与生殖特征之间的关系，研究对象为2,674,465名年龄在20-72岁的瑞典女性。与未生育妇女相比，未生育妇女患子宫内膜癌的风险显著升高。子宫内膜癌的风险随着胎次的增加而降低。 SEER特殊研究（00316）： 2001年，SEER项目补充了三个肿瘤登记处（爱荷华州、洛杉矶和夏威夷），从其集水区的病理实验室收集废弃的福尔马林固定石蜡包埋组织块。在一个示范项目中，我们使用一套现有的乳腺癌组织微阵列（tma）验证了SEERs残余组织库用于分子标记的实用性。我们的第二个SEER残留组织项目将评估基于人群的卵巢癌（OEC）估计。我们将建立卵巢癌的阵列，在对所有可用的卵巢癌病例进行系统的病理审查之后，即大约1600例。死亡率生成软件（00390）： 1999年出版的美国1950- 1994年癌症死亡率图集的在线版本可从http://www.nci.nih.gov/atlasplus获得。用户可以根据癌症、年龄、性别和种族创建定制地图。该网站已更新，包括截至2004年的数据。包含新数据的地图已经生成，并正在由DCEG的研究人员仔细检查。 记录关联研究： 退伍军人管理局住院数据库、患者治疗档案和门诊档案（00580）： 一项对退伍军人管理局（VA）住院患者数据库中多发性骨髓瘤（MM）和未确定意义单克隆γ病（MGUS）的医疗危险因素的大型研究发现，风险增加与多种自身免疫性疾病、感染性疾病和炎症性疾病相关。美国军事癌症研究所(USMCI)/NCI合作研究计划（10382）：DCEG和USMCI的研究人员正在分析900多万现役和退役军人及其家属的数据，以估计癌症发病率，并研究职业暴露和生活方式因素对癌症风险的影响。将美国现役军人的发病率与基于人群的SEER项目的发病率进行比较，发现白人男性的结直肠癌发病率、白人、黑人男性和白人女性的肺癌发病率以及黑人女性的宫颈癌发病率明显较低。