Descriptive Studies and Record Linkage

描述性研究和记录链接

• 批准号: 7593208
• 负责人: William Anderson
• 金额: $ 171.41万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7593208
• 关键词: Age; Age Distribution; Alcoholic Liver Diseases; Ambulatory Care Facilities; Anatomy; Area; Asians; Atlas of Cancer Mortality in the United States; Bile Duct Diseases; Biological Markers; Birth; Case-Control Studies; Catchment Area; Categories; Caucasoid Race; Censuses; Characteristics; Childhood; Chronic; Chronic Lymphocytic Leukemia; Chronic Sinusitis; Classification Scheme; Clinical; Colon; Colon Carcinoma; Computer software; Country; Data; Data Analyses; Data Linkages; Data Set; Databases; Denmark; Diagnosis; Distal; District of Columbia; Etiology; Evaluation; Event; Family; Female Breast Carcinoma; Fetal Distress; Formalin; Gaucher Disease; Gender; Gene Expression; Genus Cola; Goals; Hemolytic Anemia; Herpes zoster disease; Heterogeneity; Histologic; Hospitalization; Hospitals; Immune; Incidence; Inflammatory Bowel Diseases; Institutes; Intrahepatic Cholangiocarcinoma; Japan; Japanese American; Japanese Population; Laboratories; Life; Life Style; Link; Lymphoma; Malignant Bone Neoplasm; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of kidney; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Mammary Neoplasms; Maps; Medical; Medical Surveillance; Military Personnel; Minority; Molecular; Molecular Profiling; Multiple Myeloma; Neuroblastoma; Non-Hodgkin' s Lymphoma; Occupational; Occupational Exposure; Outcome; Paraffin Embedding; Pathogenesis; Pathologic; Patients; Pattern; Perinatal; Physical activity; Pneumonia; Poland; Population; Population Control; Population Registers; Prevention; Publishing; Race; Rate; Registries; Relative Risks; Renal carcinoma; Reproduction; Research; Research Personnel; Residual state; Resources; Risk; Risk Factors; Role; SEER Program; Sampling; Seminoma; Serum; Site; Small-Cell Lymphoma; Stomach Carcinoma; Subgroup; Taxonomy; Testicular Seminoma; Tissue Microarray; Tissues; United States Department of Veterans Affairs; Woman; World Health Organization; age group; base; cancer risk; cohort; early onset; epidemiology study; geographic difference; malignant breast neoplasm; malignant stomach neoplasm; melanoma; men; mortality; neoplasm registry; outcome forecast; parity; programs; prostatitis; repository; sarcoma; sex; socioeconomics; soft tissue; trend; tumor

<b>General descriptive studies (00350)</b><br>We have used incidence and mortality data from the Surveillance, Epidemiology, and End Results (SEER) program to investigate demographic patterns. An analysis of SEER data for 26,758 cases of soft tissue sarcomas regardless of primary site diagnosed during 1978-2001 found that almost half (47.9%) arose in the soft tissues; rates varied markedly by race, gender, age, and histologic type, suggesting that these tumors may be etiologically distinct. The new WHO classification scheme considers B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) in an aggregate category (CLL/SLL); however, our analysis of the SEER data revealed similarities and dissimilarities in the incidence patterns for the two malignancies. Based on registry data from 41 populations in 14 countries, cohort-specific trends in testicular seminoma and non-seminoma appeared similar, suggesting that subtypes are epidemiologically and etiologically comparable. Additional analyses are assessing the incidence patterns according to anatomic subsite and histopathologic type for several cancers including esophageal cancer, stomach cancer, lung cancer, and kidney cancer.<br><br><b>Special descriptive studies (10348)</b><br>Epidemiology studies have generally viewed breast cancer as a single biologic entity with common etiology and unified pathogenesis. Accumulating data challenge this view, suggesting that breast tumors may be categorized into several groups with distinctive epidemiological features, clinical characteristics, and outcomes. Comparison of female breast carcinoma incidence rates among native Japanese in Osaka, Japanese-Americans, Whites and Blacks in the U.S. revealed age-specific incidence differences among Occidental and Asian breast cancer populations. Age-specific rates among women in the U.S. reflected bimodal early-onset and late-onset breast cancer populations, whereas rates in Japan had mostly early-onset age distributions-at-diagnosis. Using data from a population-based case-control study in Poland, results confirmed etiologic heterogeneity by age-at-onset for certain risk factors such as parity. Parity was protective for late-onset breast cancers, but a risk factor for early-onset tumors. The reversal of relative risks by age at onset is a qualitative (crossover) age interaction, suggesting that breast cancers are fundamentally divisible into at least two main types. The 1^st breast cancer is early-onset and influenced by etiologic events, occurring early in reproduction life. The 2^nd breast cancer is late-onset and impacted by life long carcinogenic exposures.<br><br><b>SEER special studies (00316)</b><br>Analysis of gene expression profiles in breast cancer have identified intrinsic molecular subtypes, which differ in risk factor profiles and prognosis. These advances in molecular taxonomy, prevention, and treatment create a need for establishing the incidence and prognosis of specific breast cancer subtypes in various populations. However, until recently, there were limited population-based resources for these estimates. In 2001, the SEER program supplemented tumor registries to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEERs Residual Tissue Repository for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs).<br><br><b>Mortality Rate Generator Software (00390)</b><br>The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, is available at http://www.nci.nih.gov/atlasplus. Users can create customized maps according to cancer, age groups, sex, and race.<br><br><b>Evaluation of Disparities in District of Columbia (DC) (10301)</b>Newly-emerging data from the population-based DC Cancer Registry provide a unique opportunity to investigate disparities in incidence rates according to demographic, geographic, and socioeconomic characteristics. Total cancer incidence was higher among blacks than whites by 53% among men and 2% among women.<br><br><b>Record Linkage StudiesSweden and Denmark linked registries on hospital discharges and subsequent cancers (00560)</b><br>A Danish case-control study of intrahepatic cholangiocarcinoma (IC) and population controls selected from the Danish Population Register were linked to the DHDR to obtain exposure/hospital data on prior hospitalizations. IC was significantly associated with alcoholic liver disease, chronic inflammatory bowel disease, and bile duct diseases.<br><br><b>Swedish CER occupational study (02050)</b><br>Using Swedish census data from 1960 and 1970, linked to the Swedish Cancer Registry for cancer ascertainment from Jan 1, 1971 to Dec 31, 1989, occupational physical activity was found to be associated with a decreased risk of colon cancer among Swedish men and women, particularly the proximal and middle parts of the colon among women and distal colon among men.<br><br><b>Swedish childhood cancers study (00550)</b><br>A study of childhood bone cancers in the Swedish birth registry dataset found several risk factors implicating complicated delivery and fetal distress. We are also studying perinatal risk factors for neuroblastoma.<br><br><b>Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580)</b><br>A cohort of 1,500 patients with Gaucher disease was found to have 2-3-fold increased risks of non-Hodgkin lymphoma, malignant melanoma and pancreas cancer, but no significant association with multiple myeloma or cancer overall. An analysis of medical risk factors for chronic lymphocytic leukemia (CLL) found increased risk associated with chronic sinusitis, pneumonia, Herpes zoster and simplex, auto-immune hemolytic anemia and prostatitis.<br><br><b>US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382)</b><br>DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk. The wealth of information, including more than 30 million serum samples, will allow valuable studies, including research on rare cancers, cancers common among younger men, and cancers that occur more frequently in minority populations

我们使用来自监测、流行病学和最终结果（SEER）项目的发病率和死亡率数据来调查人口统计学模式。1978-2001年间，对26,758例软组织肉瘤的SEER数据分析发现，几乎一半（47.9%）出现在软组织；发病率因种族、性别、年龄和组织学类型的不同而有显著差异，表明这些肿瘤可能在病因上是不同的。世卫组织新的分类方案将b细胞慢性淋巴细胞白血病（CLL）和小淋巴细胞淋巴瘤（SLL）视为一个综合类别（CLL/SLL）；然而，我们对SEER数据的分析揭示了两种恶性肿瘤发病率模式的相似性和差异性。基于来自14个国家41个人群的登记数据，睾丸精原细胞瘤和非精原细胞瘤的队列特定趋势似乎相似，这表明亚型在流行病学和病因学上具有可比性。另外，根据食管癌、胃癌、肺癌和肾癌等几种癌症的解剖亚位点和组织病理类型，分析了其发病率模式。<br><br><b>特殊描述性研究(10348)</b><br>流行病学研究普遍认为乳腺癌是一个单一的生物学实体，具有共同的病因和统一的发病机制。越来越多的数据挑战了这一观点，表明乳腺肿瘤可能被分为具有不同流行病学特征、临床特征和结局的几组。通过对大阪日本本地人、日裔美国人、美国白人和黑人女性乳腺癌发病率的比较，揭示了西方和亚洲乳腺癌人群的年龄特异性发病率差异。美国女性的年龄特异性发病率反映了早发性和晚发性乳腺癌人群的双峰分布，而日本的发病率主要是早发性诊断年龄分布。使用波兰一项基于人群的病例对照研究的数据，结果证实了某些危险因素（如胎次）的发病年龄的病因异质性。胎次对迟发性乳腺癌有保护作用，但对早发性肿瘤却是危险因素。发病年龄对相对风险的逆转是一种定性（交叉）年龄相互作用，表明乳腺癌基本上可分为至少两种主要类型。1<sup> /sup>乳腺癌早发，受病因事件影响，发生在生殖期早期。2^和乳腺癌是晚发性的，受终身致癌暴露的影响。<br><br><b>SEER特殊研究(00316)</b><br>对乳腺癌基因表达谱的分析已经确定了内在的分子亚型，这些亚型在危险因素和预后方面存在差异。这些在分子分类学、预防和治疗方面的进展使得有必要确定不同人群中特定乳腺癌亚型的发病率和预后。然而，直到最近，用于这些估计的基于人口的资源有限。2001年，SEER项目补充了肿瘤登记，从病理学实验室收集其集水区内废弃的福尔马林固定石蜡包埋组织块。在一个示范项目中，我们使用一套现有的乳腺癌组织微阵列（tma）验证了SEERs残余组织库用于分子标记的实用性。死亡率生成软件(00390)</b><br> 1999年出版的美国1950- 1994年癌症死亡率图集的在线版本可在http://www.nci.nih.gov/atlasplus上获得。用户可以根据癌症、年龄、性别和种族创建定制地图。< br > < br > < b >的评估差异在哥伦比亚特区(DC) (10301) < / b >新兴的数据基于直流癌症登记处提供一个独特的机会,根据人口调查发病率的差异,地理和社会经济特征。黑人的癌症总发病率比白人高，男性高53%，女性高2%。<br><b>记录关联研究瑞典和丹麦医院出院和随后癌症的关联登记(00560)</b><br>丹麦肝内胆管癌（IC）的病例对照研究和从丹麦人口登记册中选择的人口对照与DHDR相关联，以获得先前住院的暴露/医院数据。IC与酒精性肝病、慢性炎症性肠病和胆管疾病显著相关。< br > < br > < b >瑞典CER职业研究(02050)< / b > < br >使用瑞典从1960年和1970年人口普查数据,与瑞典癌症癌症登记处的确定从1月1日1971年12月31日,1989年,职业体育活动被发现与降低结肠癌的风险在瑞典男性和女性,特别是近端和中间部分的男性,女性结肠远端结肠。瑞典儿童癌症研究(00550)</b><br>在瑞典出生登记数据集中对儿童骨癌进行的一项研究发现了一些涉及复杂分娩和胎儿窘迫的危险因素。我们也在研究神经母细胞瘤的围产期危险因素。< br > < br > < b >退伍军人管理局住院数据库,文件,病人治疗和门诊文件(00580)< / b > < br > 1500年一群戈谢病患者发现2-3-fold非霍奇金淋巴瘤的风险增加,恶性黑色素瘤和胰腺癌,但总体上与多发性骨髓瘤或癌症没有明显的联系。一项对慢性淋巴细胞白血病（CLL）医疗危险因素的分析发现，慢性鼻窦炎、肺炎、带状疱疹和单纯疱疹、自身免疫性溶血性贫血和前列腺炎与风险增加有关。美国军事癌症研究所(USMCI)/NCI合作研究计划（10382）DCEG和USMCI的研究人员正在分析900多万现役和退役军人及其家属的数据，以估计癌症发病率，并研究职业暴露和生活方式因素对癌症风险的影响。包括3000多万份血清样本在内的丰富信息将有助于开展有价值的研究，包括对罕见癌症、年轻男性中常见的癌症以及少数族裔人群中更常见的癌症的研究