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Descriptive Studies and Record Linkage

描述性研究和记录链接

基本信息

批准号：
7733739
负责人：
William Anderson
金额：
$ 155.13万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7733739
关键词：
Acquired Immunodeficiency Syndrome Age Ambulatory Care Facilities Anaplastic Lymphoma Anatomy Anemia Apgar Score Area Arthritis Atlas of Cancer Mortality in the United States Autoimmune Diseases B-Cell Acute Lymphoblastic Leukemia Biological Biological Markers Biology Birth Body of uterus Breast Calendar Cancer Etiology Catchment Area Categories Censuses Cervix Uteri Characteristics Childhood Childhood Lymphoma Classification Clinical Cohort Effect Cohort Studies Colon Carcinoma Communicable Diseases Computer software Cutaneous Lymphoma Data Data Analyses Data Linkages Data Set Databases Denmark Descriptive Epidemiology Detection Disease Disease susceptibility District of Columbia Division of Cancer Epidemiology and Genetics Epithelial ovarian cancer Esophageal Adenocarcinoma Esophagus Ethnic group Evaluation Family Family history of Female Breast Carcinoma Fetal Distress Formalin Gender Geographic Locations Hawaii Heterogeneity Hospitalization Hospitals Incidence India Inflammatory Inpatients Institutes Iowa Laboratories Larynx Life Style Link Liver Localized Lung Lymphoma Malignant Bone Neoplasm Malignant Childhood Neoplasm Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of male breast Malignant neoplasm of ovary Maps Medical Medical Surveillance Military Personnel Modeling Monoclonal gammopathy of uncertain significance Morphologic artifacts Multiple Myeloma National Cancer Institute Neonatal Neuroblastoma Non-Hodgkin&apos s Lymphoma Occupational Occupational Exposure Oral cavity Osteoporosis Outcome Pancreas Paraffin Embedding Pathologic Patients Pattern Personal Satisfaction Pharyngeal structure Physical activity Plasmacytoma Population Pregnancy Prostate Publishing Race Rate Registries Renal Cell Carcinoma Research Research Personnel Residual state Respiratory distress Risk Risk Factors Role Rosa SEER Program Sexually Transmitted Diseases Singapore Site Staging Stomach Subgroup Survival Analysis Sweden T-Lymphocyte Thyroid Gland Tissue Microarray Tissues United Kingdom United States United States Department of Veterans Affairs Update Variant Weight Woman age group age related base cancer risk cohort geographic difference male malignant breast neoplasm melanoma men mortality neoplasm registry programs racial and ethnic repository sex size socioeconomics trend tumor

项目摘要

General descriptive studies (00350): Our updated and expanded analysis of esophageal adenocarcinoma incidence trends among U.S. whites found that rates increased 463% among men and 335% among women from 1975-79 to 2000-04; rates rose in all stage and age groups, indicating that these increases are real and not an artifact of surveillance. Renal cell cancer incidence rates continued to rise among all racial/ethnic groups in the United States, across all age groups, and for all tumor sizes, with the most rapid increases for localized stage disease and small tumors. Plasmacytoma incidence rates overall and by site were compared with those for multiple myeloma, and variations in the patterns according to race, gender, and age suggested underlying differences in clinical detection, susceptibility, disease biology and/or etiologic heterogeneity. An analysis of cancer incidence among Indians residing in different geographic regions around the world (India, Singapore, the United Kingdom, and the United States) found that rates for cancers of the colorectum, prostate, thyroid, pancreas, lung, breast and non-Hodgkin lymphoma were lowest in India, whereas rates for cancers of the oral cavity, esophagus, larynx, and cervix uteri were highest in India. Additional analyses are assessing the incidence patterns according to anatomic subsite and histopathologic type for several cancers including the oral cavity and pharynx, stomach, lung, prostate, and thyroid, and cutaneous lymphoma, childhood lymphoma and leukemia, Burkitt lymphoma, malignant melanoma, ovarian cancer, cervical cancer, and multiple myeloma. Special descriptive studies (10348): It is widely recognized that breast cancer incidence rates overall are higher among White than Black women. However, it is not generally appreciated that age-specific incidence rates are higher for Black women aged more than 40 years and higher for White women aged more than 40 years. This so-called Black to White ethnic crossover has been well-described, not fully understood, and sometimes viewed as an artifact. We used data from the National Cancer Institute"s SEER database to assess the validity of the Black to White ethnic crossover in the United States. The Black and White ethnic crossover was a robust feature in the SEER database. Amidst recent declines for female breast cancer, age-adjusted incidence rates may be increasing for male breast cancer in the United States (US) and elsewhere. However, age-adjusted temporal trends reflect an age-specific weighted average, which may be confounded with age-related biological and/or temporal effects (period and/or cohort). We, therefore, supplemented the descriptive epidemiology of male and female breast cancer with age-period-cohort (APC) models, simultaneously adjusted for age, calendar-period, and birth-cohort effects. Results showed that male and female breast cancers demonstrated similar secular trends but different age-related biology; i.e., relatively more late-onset, low grade, and ER positive tumors among men than women. SEER special studies (00316): In 2001, the SEER program supplemented three tumor registries (Iowa, LA, and Hawaii) to collect discarded formalin-fixed, paraffin-embedded tissue blocks from pathologic laboratories within their catchment areas. In a demonstration project, we validated the utility of SEER"s Residual Tissue Repository for molecular markers, using an existing set of breast cancer tissue microarrays (TMAs). Our 2nd SEER Residual Tissue Project will assess the population-based estimates for ovarian epithelial cancers (OEC). Where the breast project used an existing set of tissue microarrays, we will build the arrays for ovarian cancer, following a systematic pathologic review of all available ovarian cancer cases, i.e., approximately 1600. Mortality Rate Generator Software (00390): The online version of the Atlas of Cancer Mortality in the United States, 1950-94, published in 1999, is available at http://www.nci.nih.gov/atlasplus. Users can create customized maps according to cancer, age groups, sex, and race. The website is being updated to include data through 2004. Evaluation of Disparities in District of Columbia (DC) (10301): Newly-emerging data from the population-based DC Cancer Registry provide a unique opportunity to investigate disparities in incidence rates according to demographic, geographic, and socioeconomic characteristics. Total cancer incidence was higher among blacks than whites by 53% among men and 2% among women. Record Linkage Studies: Sweden and Denmark linked registries on hospital discharges and subsequent cancers (00560): A Danish cohort study of osteoporosis was selected from the Danish Hospital Discharge Registry (DHDR) to obtain exposure/hospital data and linked to the Danish Cancer Registry for cancer outcomes. Osteoporosis below age 70 was significantly associated with increased risks of cancers of the buccal cavity, esophagus, liver, pancreas and lung. We also analyzed the survival patterns of lymphoma patients with a family history of lymphoma. With the exception of T-cell anaplastic lymphoma, survival patterns for patients with CLL, HL, and NHL with a family history of lymphoma were similar to those for sporadic patients. Swedish CER occupational study (02050): Using Swedish census data from 1960 and 1970, linked to the Swedish Cancer Registry for cancer ascertainment from Jan 1, 1971 to Dec 31, 1989, occupational physical activity was found to be associated with a decreased risk of colon cancer among Swedish men and women. Swedish childhood cancers study (00550): A study of childhood bone cancers in the Swedish birth registry dataset found several risk factors implicating complicated delivery and fetal distress. For neuroblastoma, increased risks were also associated with neonatal respiratory distress, as well as maternal anemia during pregnancy, and low 1-minute APGAR score. Veterans Administration hospitalization database, Patient Treatment File, and Outpatient Clinic File (00580): A large study of medical risk factors for multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) in the Veterans Administration (VA) inpatient hospitalization database found increased risk associated with broad categories of autoimmune disorders, infectious diseases and inflammatory disorders. US Military Cancer Institute (USMCI)/NCI Collaborative Research Program (10382): DCEG and USMCI researchers are analyzing data on more than 9 million active and retired military personnel and their families to estimate cancer rates as well as study the effects of occupational exposures and lifestyle factors on cancer risk.

一般描述性研究（00350）：我们对美国白人食管癌发病率趋势的更新和扩展分析发现，从1975-79年到2000-04年，男性食管癌发病率增加了463%，女性增加了335%；所有阶段和年龄组的发病率都有所上升，这表明这些增长是真实的，而不是监测的产物。肾细胞癌发病率在美国所有种族/族裔群体、所有年龄组和所有肿瘤大小中持续上升，其中局部阶段疾病和小肿瘤的发病率增长最快。浆细胞瘤的总体发病率和不同部位的发病率与多发性骨髓瘤的发病率进行了比较，根据种族、性别和年龄的模式变化表明，在临床检测、易感性、疾病生物学和/或病因异质性方面存在潜在差异。一项对居住在世界各地不同地理区域（印度、新加坡、英国和美国）的印度人癌症发病率的分析发现，结直肠癌、前列腺癌、甲状腺癌、胰腺癌、肺癌、乳腺癌和非霍奇金淋巴瘤的发病率在印度最低，而口腔癌、食道癌、喉癌和子宫颈癌的发病率在印度最高。其他的分析是根据解剖亚位点和组织病理学类型评估几种癌症的发病率模式，包括口腔和咽、胃、肺、前列腺和甲状腺、皮肤淋巴瘤、儿童淋巴瘤和白血病、伯基特淋巴瘤、恶性黑色素瘤、卵巢癌、宫颈癌和多发性骨髓瘤。特殊描述性研究（10348）：人们普遍认为，总体而言，白人妇女的乳腺癌发病率高于黑人妇女。然而，人们普遍没有认识到，40岁以上的黑人妇女和40岁以上的白人妇女的年龄特异性发病率更高。这种所谓的黑人与白人的种族交叉被很好地描述了，但没有被完全理解，有时被视为人为的。我们使用来自国家癌症研究所SEER数据库的数据来评估美国黑人与白人种族交叉的有效性。在SEER数据库中，黑人和白人的种族交叉是一个强大的特征。在最近女性乳腺癌发病率下降的同时，美国和其他地区男性乳腺癌的年龄调整发病率可能正在上升。然而，年龄调整的时间趋势反映了特定年龄的加权平均值，这可能与年龄相关的生物学和/或时间效应（时期和/或队列）相混淆。因此，我们用年龄-时期-队列（APC）模型补充了男性和女性乳腺癌的描述性流行病学，同时调整了年龄、日历-时期和出生-队列效应。结果表明，男性和女性乳腺癌表现出相似的长期趋势，但与年龄相关的生物学特征不同；也就是说，男性比女性更容易出现晚发性、低级别和ER阳性肿瘤。SEER特别研究（00316）：2001年，SEER项目补充了三个肿瘤登记（爱荷华州、洛杉矶和夏威夷），从其集水区的病理实验室收集废弃的福尔马林固定石蜡包埋组织块。在一个示范项目中，我们使用一套现有的乳腺癌组织微阵列（tma）验证了SEER残余组织库的分子标记的实用性。我们的第二个SEER残留组织项目将评估基于人群的卵巢癌（OEC）估计。在乳房项目使用现有的一套组织微阵列的情况下，我们将在对所有可用的卵巢癌病例（即大约1600例）进行系统病理审查后，为卵巢癌构建阵列。死亡率生成器软件（00390）：1999年出版的《美国1950- 1994年癌症死亡率地图集》在线版本可从http://www.nci.nih.gov/atlasplus获得。用户可以根据癌症、年龄、性别和种族创建定制地图。该网站正在更新，以包括截至2004年的数据。哥伦比亚特区（DC）差异评估（10301）：来自以人口为基础的DC癌症登记处的新数据提供了一个独特的机会，可以根据人口、地理和社会经济特征调查发病率差异。黑人的癌症总发病率比白人高，男性高53%，女性高2%。记录关联研究：瑞典和丹麦医院出院和随后癌症的关联登记（00560）：从丹麦医院出院登记（DHDR）中选择了一项丹麦骨质疏松症队列研究，以获得暴露/医院数据，并与丹麦癌症登记相关联，了解癌症结局。70岁以下的骨质疏松症患者患口腔癌、食道癌、肝癌、胰腺癌和肺癌的风险显著增加。我们还分析了有淋巴瘤家族史的淋巴瘤患者的生存模式。除t细胞间变性淋巴瘤外，有淋巴瘤家族史的CLL、HL和NHL患者的生存模式与散发性患者相似。瑞典CER职业研究（2050年）：使用瑞典1960年和1970年的人口普查数据，与瑞典癌症登记处1971年1月1日至1989年12月31日的癌症确定相关联，发现职业体育活动与瑞典男性和女性患结肠癌的风险降低有关。瑞典儿童癌症研究（00550）：在瑞典出生登记数据集中对儿童骨癌进行的一项研究发现了一些涉及复杂分娩和胎儿窘迫的危险因素。对于神经母细胞瘤，风险增加还与新生儿呼吸窘迫、妊娠期孕妇贫血和1分钟APGAR评分低有关。退伍军人管理局住院数据库、患者治疗档案和门诊档案（00580）：一项针对退伍军人管理局（VA）住院患者数据库中多发性骨髓瘤（MM）和未确定意义单克隆γ病（MGUS）的医疗危险因素的大型研究发现，自身免疫性疾病、传染病和炎症性疾病的风险增加与大类自身免疫性疾病相关。美国军事癌症研究所(USMCI)/NCI合作研究计划（10382）：DCEG和USMCI的研究人员正在分析900多万现役和退役军人及其家属的数据，以估计癌症发病率，并研究职业暴露和生活方式因素对癌症风险的影响。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States.

DOI：
10.1158/1055-9965.epi-09-0638
发表时间：
2009-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
0
作者：
Boukheris H;Curtis RE;Land CE;Dores GM
通讯作者：
Dores GM

Chronic immune stimulation and subsequent Waldenström macroglobulinemia.

慢性免疫刺激和随后的华氏巨球蛋白血症。

DOI：
10.1001/archinternmed.2008.4
发表时间：
2008-09-22
期刊：
ARCHIVES OF INTERNAL MEDICINE
影响因子：
0
作者：
Koshiol, Jill;Gridley, Gloria;Engels, Eric A.;McMaster, Mary L.;Landgren, Ola
通讯作者：
Landgren, Ola

Prenatal and perinatal risk factors for neuroblastoma.