BRAIN AGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类在灵长类动物中是独一无二的，因为他们容易受到与年龄相关的神经退行性疾病的影响，特别是阿尔茨海默氏症，众所周知，这种疾病只在人类中自然发生。 在本报告所述期间，我们探讨了人类、黑猩猩(与人类关系最密切的动物)和猕猴(在神经科学研究中经常被用作人类模型的灵长类)大脑结构随年龄变化的异同。我们使用神经成像技术来识别年轻人、中年人和老年人灰质体积、白质体积和白质完整性的年龄相关变化，并对在研究过程中死亡的任何动物的脑组织变化进行了尸检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Humans are unique among primates in their vulnerability to age-related neuro-degenerative disease, especially Alzheimer's disease, which is known to occur naturally only among humans. During the reporting period, we explored similarities and differences in age-related changes in brain structure in humans, in chimpanzees (the animals most closely related to humans), and in macaque monkeys (primates that are often used as models for humans in neuroscientific research). We used neuroimaging techniques to identify age-related changes in gray matter volume, white matter volume, and white matter integrity in young adults, middle-aged adults, and elderly individuals, and carried out postmortem microscopic examination of brain-tissue changes of any animals that died during the course of the study.