CONTRACEPTION BY BLOCKADE OF PERIOVULATORY EVENTS IN PRIMATES (U54 CENTER)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 俄勒冈州国家灵长类研究中心和俄勒冈健康与科学大学成立了U54避孕药开发研究中心，旨在发现和开发新型避孕药，防止一种或多种 月经周期中成年雌性灵长类动物的排卵事件。三个研究项目和一个动物核心利用东半球(猕猴)猴子产生新的信息和概念验证，以防止妇女受精，从而防止生育。项目一“控制卵母细胞成熟”将解决这样的假设，即新的卵泡细胞和卵母细胞来源于 蛋白质控制卵母细胞的核和细胞质成熟，并可被利用来扰乱适时的卵子成熟。项目二“控制排卵”将分析控制卵丘-卵母细胞扩张和卵泡破裂的卵泡/卵丘和卵母细胞来源的蛋白质，并测试拮抗剂是否能阻止排卵和卵子释放。项目III，“配子运输和受精的控制”验证了雌激素作用对正常输卵管和宫颈功能至关重要的假设，即选择性雌激素受体调节剂(SERM)将扰乱配子运输，从而影响受精。在项目I-III中发现的有希望的药物将在非人类灵长类避孕药核心中进行避孕有效性和可逆性测试。与制药业和妇产科的现有联系将促进与为妇女研制新型卵巢/生殖道避孕药具相关的翻译研究。有关进度报告和出版物，请参阅个别项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Oregon National Primate Research Center and the Oregon Health & Science University established a U54 Contraceptive Development Research Center that targets the discovery and development of novel contraceptive drugs that prevent one or more periovulatory events in adult, female primates during the menstrual cycle. Three research projects and one animal core utilize Old World (macaque) monkeys to generate new information and proof-of-concept regarding modalities that prevent oocyte fertilization, and hence fertility, in women. Project I, "Control of Oocyte Maturation", will address the hypothesis that novel follicle cell-, and oocyte-derived proteins control nuclear and cytoplasmic maturation of the oocyte, and can be exploited to disrupt timely egg maturation. Project II, "Control of Ovulation", will analyze follicle/cumulus- and oocyte-derived proteins that control cumulus-oocyte expansion and follicle rupture, and test whether antagonists prevent ovulation and egg release. Project III, "Control of Gamete Transport and Fertilization" tests the hypothesis that estrogen action is essential for normal oviductal and cervical function, such that a selective estrogen receptor modulator (SERM) will disrupt gamete transport, and hence, fertilization. Promising agents discovered in Projects I - III will be tested in the Nonhuman Primate Contraceptive Core for contraceptive efficacy and reversibility. Existing ties with the pharmaceutical industry and OB/GYN, OHSU, will promote translational research relevant to formulating novel ovary/reproductive tract-based contraceptives for women. See individual projects for progress reports and publications.