Vanderbilt Mouse Metabolic Phenotyping Center

描述（由申请人提供）：范德比尔特小鼠代谢表型中心（VMMPC）成立于2001年，旨在通过为科学界提供糖尿病、糖尿病并发症和肥胖小鼠模型的标准化、高质量表型服务来推进医学和生物学研究。VMMPC由五个核心组成。行政核心提供科学，财务和行政领导。该核心还监督服务请求，数据管理，并跟踪VMMPC研究的小鼠。行政核心还负责VMMPC教育方案。动物健康和福利中心评估提交给VMMPC的小鼠，监督殖民地的健康和福利，并确保遵守监管机构和MMPC指南。代谢病理生理学中心（MPC）提供的服务强调研究清醒无压力小鼠的能量平衡、胰岛素作用、激素分泌和代谢的方法。MPC还具有单独评估器官或胰岛功能的能力，并可以应用最先进的成像技术。心血管病理生理学和并发症核心有一系列的测试来研究心血管疾病和糖尿病的其他并发症。分析资源核心接收从VMMPC测试和从VMMPC外部进行的实验生成的样品。该核心执行的分析特定于小鼠，并按比例调整以适应小样本体积。VMMPC的存在是因为NIDDK领导层的洞察力，VUMC对空间和资源的慷慨承诺，以及精心设计的基础设施。但VMMPC之所以能发挥作用，主要原因在于它的组成人员。NIDDK在小鼠表型分析方面的实验需要一个愿意将其研究生命线的一部分技术提供给科学界的教师，而不仅仅是收回成本和他们正在为更大的利益而工作的知识。它需要一个如此熟练和忠诚的工作人员，以至于科学家们愿意把他们的老鼠，他们的研究生命线，托付给他们。 公共卫生相关性：范德比尔特小鼠代谢表型中心通过向科学界提供最先进的表型分析服务，提高了对糖尿病、肥胖和相关疾病的认识。

DESCRIPTION (provided by applicant): The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership. This Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Administrative Core is also responsible for the VMMPC educational program. The Animal Health and Welfare Core evaluates mice submitted to the VMMPC, oversees the health and welfare of the colony, and ensures compliance with regulatory bodies and MMPC guidelines. Services provided by the Metabolic Pathophysiology Core (MPC) emphasize methodology to study energy balance, insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MPC also has the capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The Cardiovascular Pathophysiology and Complications Core has a range of tests to study cardiovascular disease and other complications of diabetes. The Analytical Resources Core receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by this core are specific to the mouse and are scaled to accommodate small sample volumes. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from VUMC, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is the people that comprise it. This NIDDK experiment in mouse phenotyping requires a faculty that is willing to make technology that is part of their research lifeline available to the scientific community for no more than the recovery of costs and the knowledge that they are working for a greater good. It requires a staff that is so skilled and committed that scientists are willing to entrust their mice, their research lifelines, with them. PUBLIC HEALTH RELEVANCE: The Vanderbilt Mouse Metabolic Phenotyping Center advances knowledge of diabetes, obesity, and related disorders by providing state-of-the-art phenotyping services to the scientific community.