CSHL 2011 Cellular Biology of Addiction Course

描述（由申请人提供）：本次研讨会的主要目的是就药物成瘾的细胞和分子生物学的基本原理、最新进展和主要差距进行深入讨论。本次研讨会将结合正式的演讲和非正式的讨论，针对新的和有经验的研究人员，传达细胞和分子方法对药物成瘾研究的优点和令人兴奋的地方。研讨会将强调这种方法的重要性，不仅对最昂贵的神经精神障碍，成瘾，但其适用性的学习，记忆，神经化学相关的奖励，感知和其他学科的神经科学。对药物反应中发生的分子和细胞变化的研究对于阐明成瘾的每个阶段和每种药物滥用的适应过程是否不同至关重要。随着基因组学和蛋白质组学的出现，现在存在一个非凡的机会来开发成瘾，渴望和吸毒复发的基础神经适应过程的综合模型。讲习班将为与会者提供一系列学科，这些学科有助于开发药物成瘾每个阶段的综合模型。将介绍以下学科：1。成瘾概述。2. 对滥用药物的神经适应。3. 药物诱导的神经适应与行为表现的关系对药物成瘾或药物反应的基因型/易感性。5. 细胞水平上的耐受、敏化和适应。6. 新的受体靶点。7. 治疗药物滥用的药物发现和开发：细胞生物学如何发挥作用？本次研讨会将提供对成瘾的神经适应性反应的当前和新研究的综合观点，促进对合作和整合的讨论，并提供构建成瘾作为一种疾病的模型和生物治疗的新分子靶点所需的关键信息。在科学研究的层面之外，这些信息对于制定公共政策和启发公众对药物使用和成瘾的神经生物学后果至关重要。提议的研讨会将产生强烈的兴趣，开放的合作渠道和研究成瘾的神经生物学的新途径。该研讨会特别努力包括一个多样化的参与者群体，特别注意包括妇女、美国少数民族和国内和国际科学家的良好平衡。

DESCRIPTION (provided by applicant): The primary objective of the proposed workshop is to provide an intense discussion of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new and experienced investigators, the workshop will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, neurochemical correlates of reward, perception and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, craving, and relapse to drug use. The workshop will provide attendees with a spectrum of disciplines that can contribute to developing comprehensive models of each stage of drug addiction. The following disciplines will be presented: 1.Overview of addiction. 2. Neuroadaptation to drugs of abuse. 3. Association between drug-induced neuroadaptation and behavioral manifestations 4. Genotype/susceptibility to drug addiction or drug response. 5. Tolerance, sensitization and adaptation at the cellular level. 6. New receptor targets. 7. Drug discovery and development to treat drug abuse: how can cell biology contribute? This workshop will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration and provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, such information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The proposed workshop will generate intense interest, open conduits for collaborations and novel routes to investigating the neurobiology of addiction. The workshop makes particular efforts to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists. PUBLIC HEALTH RELEVANCE: The societal consequences of drug addiction and abuse are enormous. Over the past thirty years, behavioral studies have tended to dominate the field of addiction research. With the rapid growth in molecular neuroscience in the last two decades and the completion of the human genome in 2003, integration between behavioral or physiological responses and molecular genetic and cellular responses is increasingly possible and relevant. Amalgamation of these disciplines requires a profound appreciation for the strengths and weaknesses of each approach. The theme of the workshop is to provide attendees with the most up-to-date information on how tissues, cells and genes respond to drugs of abuse, within the framework of the behavioral effects of addictive drugs. This week-long residential workshop is targeted to both new and experienced investigators, and combines formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. Ultimately, new treatments for these disorders are likely to emerge from a better understanding of the underlying processes that go awry during substance abuse and addiction.