Immersion in Drug Abuse

沉浸在药物滥用中

• 批准号: 8056794
• 负责人: ESTELLE B. GAUDA
• 金额: $ 33.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8056794
• 关键词: Adolescence; Adolescent Medicine; Adverse effects; Age; Behavior; Biology; Birth; Brain; Development; Doctor of Medicine; Doctor of Philosophy; Drug Addiction; Drug Metabolic Detoxication; Drug Tolerance; Drug abuse; Drug usage; Education; Family; Fetus; Goals; Grant; Human; Illicit Drugs; Immersion Investigative Technique; Intervention; Learning; Mediating; Medical Students; Medical center; Mission; NIH Program Announcements; National Institute of Drug Abuse; Newborn Infant; Opiate Addiction; Opiates; Pharmaceutical Preparations; Physicians; Pregnancy; Pregnant Women; Prevention strategy; Reporting; Research; Research Personnel; Research Training; Risk-Taking; Scientist; Staging; Students; Surveys; Training; Training Programs; United States; Universities; Woman; addiction; alternative treatment; base; career; design; experience; fetal; nervous system development; next generation; novel; pediatric department; pregnant; programs; psychosocial; reproductive; response

DESCRIPTION (provided by applicant): A NIDA conducted national survey reported that 5.5% of 4 million women who gave birth in the United States in 1992 used illegal drugs while they were pregnant. In addition to the psychosocial ramifications, illicit drug use also has adverse effects on the development of the nervous system in the fetus and newborn and increases the possibilities of risk taking behavior in adolescence. Little is known about the biology of addiction to illicit drugs in the developing fetus and newborn and few investigators specialize in this important field. In response to the program announcement (PAR-04-054), Research Education Grants in Drug Abuse and Addiction, the overall goal of this proposal is to bring together the scientific and educational expertise in drug abuse research at Johns Hopkins and Morgan State University to create a novel educational/research training program with the mission of training researchers in the basic biology and psychosocial aspects of illicit drug use in the young woman entering reproductive age, the pregnant woman, and her fetus and newborn. Under the co-directorship of Estelle Gauda, M.D., a physician-scientist at Johns Hopkins, and Gabrielle McLemore, Ph.D., a educator-scientist at Morgan State University, we have created a partnership between investigators from the Center for Addiction and Pregnancy at Johns Hopkins Bayview Medical Center, the Kennedy Krieger Family Center, the Department of Pediatrics and Adolescent Medicine at Johns Hopkins University, and Morgan State University to accomplish this goal through 2 educational programs. The Summer Immersion in Drug Abuse Research Program (SIDARP) is a 10 week educational-research/training experience which will target doctoral students, medical students, and physicians at an early stage of their professional careers. The Drug Abuse Research Training (DART) Program is a long-term (2-3 years) research experience designed to target pre and postdoctoral students and clinician-scientists to be the next generation of leaders in the field of drug addiction and abuse research and education. The training program will use a competency based learning strategy to maximize learning. Emphasis will be given to having educational and research opportunities that will include basic mechanisms mediating drug dependence and tolerance in the fetus and newborn, effects of opiate exposure on human fetal behavior and newborn brain development, alternative treatment and detoxification strategies for opiate addiction during pregnancy and in the newborn, and drug abuse intervention and prevention strategies in women of reproductive age.

NIDA进行的一项全国性调查报告称，1992年在美国分娩的400万妇女中有5.5%在怀孕期间使用非法药物。除了心理社会后果外，非法药物使用还对胎儿和新生儿的神经系统发育产生不利影响，并增加了青春期冒险行为的可能性。对发育中的胎儿和新生儿对非法药物成瘾的生物学知之甚少，很少有研究人员专门研究这一重要领域。为了回应节目预告（PAR-04-054），药物滥用和致瘾研究教育赠款，该提案的总体目标是汇集约翰·霍普金斯大学和摩根州立大学在药物滥用研究方面的科学和教育专业知识，以创建一个新颖的教育/研究培训方案，其使命是对研究人员进行进入生育年龄的年轻妇女使用非法药物的基本生物学和心理社会方面的培训，孕妇和她的胎儿及新生儿在埃斯特尔·高达医学博士的共同指导下，约翰霍普金斯的一位物理学家兼科学家，和加布里埃尔·麦克莱莫尔博士，作为摩根州立大学的教育家和科学家，我们在约翰霍普金斯湾景医疗中心成瘾和怀孕中心、肯尼迪克里格家庭中心、约翰霍普金斯大学儿科和青少年医学系以及摩根州立大学的研究人员之间建立了伙伴关系，通过2个教育项目来实现这一目标。药物滥用研究计划（SIDARP）的夏季沉浸是一个为期10周的教育研究/培训经验，将针对博士生，医学生和医生在他们的职业生涯的早期阶段。药物滥用研究培训（DART）计划是一项长期（2-3年）的研究经验，旨在针对博士前和博士后学生和临床科学家成为药物成瘾和滥用研究和教育领域的下一代领导者。培训计划将使用基于能力的学习策略，以最大限度地提高学习效果。重点将是提供教育和研究机会，其中将包括调节胎儿和新生儿药物依赖和耐受性的基本机制，阿片剂暴露对人类胎儿行为和新生儿大脑发育的影响，怀孕期间和新生儿阿片剂成瘾的替代治疗和解毒战略，以及育龄妇女药物滥用干预和预防战略。

项目成果

Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.

Narp 基因敲除小鼠对新奇事物表现出正常的反应性，但从恐惧症中恢复的能力减弱。

• DOI: 10.1016/j.bbr.2013.10.001
• 发表时间: 2013
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Blouin,AshleyM;Lee,JongahJ;Tao,Bo;Smith,DaniR;Johnson,AlexanderW;Baraban,JayM;Reti,IrvingM
• 通讯作者: Reti,IrvingM

Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.

• DOI: 10.1016/j.pain.2010.07.017
• 发表时间: 2010-10
• 期刊: Pain
• 影响因子: 7.4
• 作者: Atianjoh FE;Yaster M;Zhao X;Takamiya K;Xia J;Gauda EB;Huganir RL;Tao YX
• 通讯作者: Tao YX

Comparison of cigarette smoking knowledge, attitudes, and practices among staff in perinatal and other substance abuse treatment settings.

• DOI: 10.1097/adm.0000000000000068
• 发表时间: 2014-09
• 期刊: Journal of addiction medicine
• 影响因子: 5.5
• 作者: Miller-Thomas T;Leoutsakos JM;Terplan M;Brigham EP;Chisolm MS
• 通讯作者: Chisolm MS

Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells.

• DOI: 10.1038/jp.2012.124
• 发表时间: 2013-05
• 期刊: JOURNAL OF PERINATOLOGY
• 影响因子: 2.9
• 作者: Chavez-Valdez, R.;Kovell, L.;Ahlawat, R.;McLemore, G. L.;Wills-Karp, M.;Gauda, E. B.
• 通讯作者: Gauda, E. B.