University of Michigan Comprehensive Cancer Center Support Grant

密歇根大学综合癌症中心支持补助金

• 批准号: 7917284
• 负责人: MAX S. WICHA
• 金额: $ 599.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917284
• 关键词: University; Michigan; Comprehensive; Cancer; Center

DESCRIPTION (provided by applicant): The University of Michigan Comprehensive Cancer Center (UMCCC) requests renewal of its core grant in support of Senior Leadership, Programs, and Shared Core Facilities. A core grant to support the UMCCC was initially awarded by the NCI in 1988, with continuous funding since then. Dr. Max Wicha, the founding Director of the Cancer Center, continues to serve as Director. The Center provides an organizational framework to promote interdisciplinary cancer research through the development of defined clinical, basic, and prevention programs in cancer research and the development of shared core resources. In 1997 the Center moved into a new $88 million facility which houses the Center's outpatient clinics as well as many of its research laboratories. The Cancer Center has continued to experience considerable growth over this grant period with 70 new faculty recruited and an 85% increase in NCI funding. The Cancer Center's 13 research programs include the basic research programs in Cancer Genetics, Cancer Cell Biology, Molecular Therapeutics, Radiation Sciences, and Molecular Imaging. Clinical research programs include Prostate/Urological, Breast, Leukemia/Lymphoma-BMT, Gl, Childhood Cancers, and Head & Neck cancers. The prevention programs include two programs: Biomedical Prevention and Socio-Behavioral. Support is requested for a total of 16 shared core facilities. These include Clinical Trials, Biostatistics, Tissue Procurement, Tumor Imaging, DNA Sequencing, Morphology, Flow Cytometry, Experimental Irradiation, Animal Facility, Transgenic Mouse, Vector Core, Immune Monitoring, cDNA Affymetrix and Microarray and three new cores including Proteomics, Bioinformatics, and Health Communications. Funds are also requested for development, planning and evaluation, and administration to support Center goals. The Medical Center has made substantial commitments to the Cancer Center of approximately $175 million. Its 285 UMCCC members receive over $82 million in research funding, including over $37 million in annual direct NCI support. The UMCCC has had a major impact on cancer research as evidenced by publishing at least 315 articles in high impact journals, placing 52% of UMCCC intervention accruals onto investigator-initiated trials and consistently ranking among the top ten Cancer Centers nationally for NCI funding over this grant period.

描述（由申请人提供）：密歇根大学综合癌症中心（UMCCC）要求更新其核心补助金，以支持高级领导，计划和共享核心设施。 1988年，NCI最初提供了一笔支持UMCCC的核心赠款，此后一直提供资金。 癌症中心的创始主任Max Wicha博士继续担任主任。 该中心提供了一个组织框架，以促进跨学科的癌症研究，通过在癌症研究中定义的临床，基础和预防计划的发展和共享的核心资源的发展。 1997年，该中心搬进了一个新的8800万美元的设施，其中包括该中心的门诊诊所以及许多研究实验室。 癌症中心继续经历了相当大的增长，在此期间与70名新教师招聘和NCI资金增加85%。 癌症中心的13个研究项目包括癌症遗传学、癌细胞生物学、分子治疗学、放射科学和分子成像的基础研究项目。 临床研究项目包括前列腺/泌尿系统，乳腺癌，白血病/淋巴瘤-BMT，GI，儿童癌症和头颈癌。 预防方案包括两个方案：生物医学预防和社会行为。 共请求为16个共享核心设施提供支助。 其中包括临床试验，生物统计学，组织采购，肿瘤成像，DNA测序，形态学，流式细胞术，实验辐照，动物设施，转基因小鼠，载体核心，免疫监测，cDNA亲和素和微阵列和三个新的核心，包括蛋白质组学，生物信息学和健康通讯。 还要求提供资金用于发展、规划和评估以及行政管理，以支持中心的目标。 该医疗中心已向癌症中心作出约1.75亿美元的实质性承诺。 其285个UMCCC成员获得超过8200万美元的研究资金，其中包括超过3700万美元的年度直接NCI支持。 UMCCC对癌症研究产生了重大影响，在高影响力期刊上发表了至少315篇文章，将52%的UMCCC干预应计费用投入到了制药商发起的试验中，并在此资助期内一直名列全国NCI资助的十大癌症中心之列。