University of Michigan Comprehensive Cancer Center Support Grant

描述（由申请人提供）：密歇根大学综合癌症中心（UMCCC）要求更新其核心资助，以支持高级领导，项目和共享核心设施。NCI最初于1988年为UMCCC提供了一笔核心赠款，此后一直在提供资金。Max Wicha博士，癌症中心创始主任，继续担任主任。该中心提供了一个组织框架，通过制定明确的癌症研究临床、基础和预防项目以及共享核心资源的开发来促进跨学科癌症研究。1997年，该中心搬进了一个价值8800万美元的新设施，其中包括该中心的门诊诊所以及许多研究实验室。在此期间，癌症中心继续经历了相当大的增长，招募了70名新教师，NCI的资金增加了85%。癌症中心的13个研究项目包括癌症遗传学、癌细胞生物学、分子治疗学、放射科学和分子成像的基础研究项目。临床研究项目包括前列腺/泌尿外科、乳腺癌、白血病/淋巴瘤- bmt、Gl、儿童癌症和头颈部癌症。预防方案包括两个方案：生物医学预防和社会行为。要求为总共16个共享核心设施提供支助。其中包括临床试验、生物统计学、组织获取、肿瘤成像、DNA测序、形态学、流式细胞术、实验照射、动物设施、转基因小鼠、载体核心、免疫监测、cDNA Affymetrix和微阵列，以及三个新的核心，包括蛋白质组学、生物信息学和健康通讯。资金也被要求用于发展、规划和评价，以及支持中心目标的管理。医疗中心已向癌症中心作出了约1.75亿美元的实质性承诺。它的285名UMCCC成员获得了超过8200万美元的研究经费，其中包括每年超过3700万美元的NCI直接支持。UMCCC对癌症研究产生了重大影响，在高影响力期刊上发表了至少315篇文章，将52%的UMCCC干预应计费用用于研究者发起的试验，并且在此资助期间一直位居NCI资助的全国十大癌症中心之列。

DESCRIPTION (provided by applicant): The University of Michigan Comprehensive Cancer Center (UMCCC) requests renewal of its core grant in support of Senior Leadership, Programs, and Shared Core Facilities. A core grant to support the UMCCC was initially awarded by the NCI in 1988, with continuous funding since then. Dr. Max Wicha, the founding Director of the Cancer Center, continues to serve as Director. The Center provides an organizational framework to promote interdisciplinary cancer research through the development of defined clinical, basic, and prevention programs in cancer research and the development of shared core resources. In 1997 the Center moved into a new $88 million facility which houses the Center's outpatient clinics as well as many of its research laboratories. The Cancer Center has continued to experience considerable growth over this grant period with 70 new faculty recruited and an 85% increase in NCI funding. The Cancer Center's 13 research programs include the basic research programs in Cancer Genetics, Cancer Cell Biology, Molecular Therapeutics, Radiation Sciences, and Molecular Imaging. Clinical research programs include Prostate/Urological, Breast, Leukemia/Lymphoma-BMT, Gl, Childhood Cancers, and Head & Neck cancers. The prevention programs include two programs: Biomedical Prevention and Socio-Behavioral. Support is requested for a total of 16 shared core facilities. These include Clinical Trials, Biostatistics, Tissue Procurement, Tumor Imaging, DNA Sequencing, Morphology, Flow Cytometry, Experimental Irradiation, Animal Facility, Transgenic Mouse, Vector Core, Immune Monitoring, cDNA Affymetrix and Microarray and three new cores including Proteomics, Bioinformatics, and Health Communications. Funds are also requested for development, planning and evaluation, and administration to support Center goals. The Medical Center has made substantial commitments to the Cancer Center of approximately $175 million. Its 285 UMCCC members receive over $82 million in research funding, including over $37 million in annual direct NCI support. The UMCCC has had a major impact on cancer research as evidenced by publishing at least 315 articles in high impact journals, placing 52% of UMCCC intervention accruals onto investigator-initiated trials and consistently ranking among the top ten Cancer Centers nationally for NCI funding over this grant period.