BIOINFORMATICS CORE

生物信息学核心

• 批准号: 8167429
• 负责人: CAROLYN J HOVDE
• 金额: $ 41.81万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167429
• 关键词: Administrator; Area; Arts; Award; Bioinformatics; Biomedical Research; Budgets; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Computer software; Data Storage and Retrieval; Databases; Educational process of instructing; Faculty; Fee-for-Service Plans; Funding; Gene Expression; Grant; High Performance Computing; Human Resources; Idaho; Individual; Institution; Institutional National Research Service Award; Internet; Participant; Phylogenetic Analysis; Power Sources; Process; Proteomics; Research; Research Personnel; Resources; Secure; Signal Transduction; Source; Speed; Statistical Models; Students; System; Telecommunications; Training; United States National Institutes of Health; Universities; Wages; cluster computing; computer cluster; instrumentation; mass spectrometer; protein structure; research facility

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Bioinformatics Core established technological and human resources that support biomedical research in Idaho. Bioinformatics is incorporated into activities at various levels on every Idaho campus as evidenced by separate INBRE bioinformatics budgets by most Network institutions. To maintain critical mass in three types of bioinformatics analyses used in "Cell Signaling" research, areas of emphasis will continue in (i) evolutionary analysis (UI), (ii) gene expression analysis (ISU), and (iii) protein structure analysis and proteomics (BSU). UI will host local databases and a distributed cluster computer for statistical modeling and phylogenetic estimation. ISU will host a distributed cluster computer and software tightly integrated with their high throughput sequencing facility. BSU will host a distributed cluster computer and software tightly integrated with their mass spectrometer facility. Each facility will be available to faculty and students in every state institution via high-speed telecommunications. The high-end computing hardware will remain available to all INBRE participants through secure internet connections and access to state-of-the art analytical software, and experts will provide specialized help as necessary. The facilities received COBRE (UI) or instrumentation (BSU, ISU) awards, substantial material support from each university administration, and support from individual NIH and NSF research awards. In particular, a UI COBRE (LJ Forney, PI), which was recently renewed for five years, will fund additional processing capacity for cluster computing. Bioinformatics hardware and software needs will be optimized statewide for educating and training students and faculty in best-bioinformatics-practices and providing access to specialized high performance computing. Planned upgrades include, at UI, power supplies, servers and cluster nodes, increase disk storage capacity, and transfer of all bioinformatics system administrators to permanent Idaho State salaries; at ISU, computing nodes and data storage and building an integrated bioinformatics teaching/research facility; at BSU, integrating a new mass spectrometer and software, adding two general-purpose servers, increasing data storage capacity, expanding cluster computing capacity, and supporting additional staff on a permanent state line. BSU will also significantly enhance its telecommunications connections by leveraging INBRE funds with NSF instrumentation awards, institutional support, and service fees in individual grants.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 生物信息学核心建立了支持爱达荷州生物医学研究的技术和人力资源。生物信息学被纳入爱达荷州每个校园的各个级别的活动中，大多数网络机构单独的 INBRE 生物信息学预算证明了这一点。 为了保持“细胞信号传导”研究中使用的三种生物信息学分析的临界质量，重点领域将继续是（i）进化分析（UI），（ii）基因表达分析（ISU）和（iii）蛋白质结构分析和蛋白质组学（BSU）。 UI 将托管本地数据库和分布式集群计算机，用于统计建模和系统发育估计。 ISU 将托管分布式集群计算机和与其高通量测序设施紧密集成的软件。 BSU 将托管与其质谱仪设施紧密集成的分布式集群计算机和软件。 每个州立机构的教师和学生都可以通过高速电信使用每个设施。所有 INBRE 参与者都将通过安全的互联网连接和最先进的分析软件来使用高端计算硬件，专家将在必要时提供专业帮助。 这些设施获得了 COBRE (UI) 或仪器（BSU、ISU）奖项、各大学行政部门的大量物质支持以及 NIH 和 NSF 各个研究奖项的支持。特别是，最近更新了五年的 UI COBRE（LJ Forney，PI）将为集群计算提供额外的处理能力。 生物信息学硬件和软件需求将在全州范围内进行优化，以教育和培训学生和教师进行最佳生物信息学实践，并提供专业高性能计算的机会。计划的升级包括用户界面、电源、服务器和集群节点，增加磁盘存储容量，以及将所有生物信息学系统管理员转为爱达荷州立大学的永久工资；在ISU，计算节点和数据存储以及建设综合生物信息学教学/研究设施；在 BSU，集成了新的质谱仪和软件，添加了两台通用服务器，增加了数据存储容量，扩展了集群计算能力，并支持永久州线上的额外工作人员。 BSU 还将利用 INBRE 资金和 NSF 仪器奖励、机构支持和个人赠款中的服务费，显着增强其电信联系。