YEAST SPINDLE ASSEMBLY

酵母主轴组件

• 批准号: 8171460
• 负责人: Trisha N. Davis
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171460
• 关键词: Area; Cells; Chromosomes; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Genetic Materials; Grant; Institution; Kinetochores; Lead; Malignant Neoplasms; Mitotic; Mitotic spindle; Molecular Machines; Pharmaceutical Preparations; Regulation; Research; Research Personnel; Resources; Signal Transduction; Site; Source; United States National Institutes of Health; Yeasts; cancer cell; cancer therapy; disability; success; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proper transmission of genetic material requires the correct assembly and function of a molecular machine called the mitotic spindle. Errors in spindle assembly result in missegregation of the chromosomes and can lead to disability and cancer. Some cancer cells over express components of the kinetochore. The kinetochore, critical for correct spindle assembly, is a site of regulation and checkpoint signaling. Because errors in spindle assembly result in disease, it is important to understand the precise function of each spindle component. Already, cancer therapies targeting mitotic cells have been used with great success. Continued research in this area will lead to new, more specific drugs, whose primary target is diseased cells.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 遗传物质的正确传递需要被称为有丝分裂纺锤体的分子机器的正确组装和功能。 纺锤体组装中的错误会导致染色体的错误分离，并可能导致残疾和癌症。 一些癌细胞过度表达动粒的成分。 动粒是一个调控和检查点信号传导的位点，对纺锤体的正确组装至关重要。 由于主轴装配错误会导致疾病，因此了解每个主轴部件的精确功能非常重要。 针对有丝分裂细胞的癌症疗法已经取得了巨大成功。 在这一领域的持续研究将导致新的，更具体的药物，其主要目标是病变细胞。