COPPER SPECIATION IN PROSTATE & BREAST CANCER

前列腺中的铜形态

• 批准号: 8168645
• 负责人: RAUL BARREA
• 金额: $ 5.21万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168645
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Copper; Funding; Grant; Institution; Mammary Neoplasms; Measurement; Prostate; Research; Research Personnel; Resolution; Resources; Sampling; Scanning; Source; Spectrum Analysis; System; Testing; Thick; Tumor Tissue; United States National Institutes of Health; Work; absorption; design; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have designed three new sets of Bent Laue Crystal Analyzers for Cu K edge XANES measurements. The analyzers consist of an Al bender system and Si (111) crystal of different thicknesses in order to provide more flux or higher energy resolution depending on their final application. We have tested all three sets of analyzers using a microbeam of 5 microns FWHM and Cu foil as standard sample. The beam was set at the Cu K edge energy and it was scanned in the region of the Cu absorption edge. We found that analyzers set number 1, which has a large working distance, presented better resolution than the others with moderate count rate. The second set of analyzers showed the optimum combination of count rate and resolution. The third set presents very good count rate with poor resolution. These results will allow us to continue our proposal of high resolution spectroscopy in prostate and breast tumor tissues.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们设计了三台新的Bent-Laue晶体分析仪，用于测量CuK边XANES。该分析仪由铝弯曲系统和不同厚度的Si(111)晶体组成，以提供更多的熔剂或更高的能量分辨率，具体取决于它们的最终应用。我们用5微米半高宽的微束和铜箔作为标准样品对三套分析仪进行了测试。将束流设置在铜K边能量处，在铜吸收边区域进行扫描。我们发现，工作距离较大的1号分析仪的分辨率比其他计数率适中的仪器的分辨率要高。第二套分析仪显示了计数率和分辨率的最佳组合。第三组显示了很好的计数率，但分辨率很低。这些结果将使我们能够继续在前列腺和乳腺肿瘤组织中进行高分辨率光谱分析的提议。