High-Throughput Structural Biology

描述（由申请人提供）：该提案要求支持由Ian A.威尔逊，Aled M.爱德华兹亨德尔和安德烈萨利，这将是在基斯通，科罗拉多从2012年1月22日至27日举行。结构生物学仍然是生物学和生物医学发现的最多产和信息量最大的方法之一，并为生物系统提供基本的分子见解。测序基因组数量的迅速增加为结构生物学家提供了大量新的机遇和挑战，以探索生物大分子的巨大多样性及其与功能，进化和疾病的关系。会议的目标是探索结构生物学的当前进展和前沿，并说明X射线晶体学和NMR的高通量方法-结合使用计算和其他生物物理技术的混合方法（包括CryoEM，X射线和电子断层扫描，SAXS，质谱，蛋白质组学）-可用于解决分子，细胞和化学生物学中的局部和挑战性问题。本次研讨会将集中在各种途径和方法，可用于结构生物学家和生物学家的生物系统及其组成大分子和复合物的调查。我们还将通过两次公开辩论讨论一些与该领域非常相关的专题。与会者还将有机会扩大他们对复杂生物系统的理解，这些系统可以通过结构-功能-生物组织姐妹会议从结构生物学的这些当前进展中受益-该会议将与本次会议分享一个主题演讲和两个全体会议。 公共卫生相关性：结构基因组学领域包括确定蛋白质和其他大分子的三维结构和功能的尖端实验方法。这些技术使科学界能够跟上从基因组测序工作中获得的丰富信息的步伐。Keystone Symposia高通量结构生物学会议将专注于如何解决具有挑战性的蛋白质，生物系统和整个生物体，以及如何填补我们对蛋白质宇宙的知识空白，这已经从大量的基因组序列中变得显而易见，其中生物功能是未知的。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled High-Throughput Structural Biology, organized by Ian A. Wilson, Aled M. Edwards, Tracy M. Handel and Andrej Sali, which will be held in Keystone, Colorado from January 22 - 27, 2012. Structural Biology continues to be one of the most prolific and informative ways to make biological and biomedical discoveries, and provides fundamental molecular insights into biological systems. The rapidly expanding numbers of sequenced genomes is providing structural biologists with a wealth of new opportunities and challenges to explore the enormous diversity of biological macromolecules and their relationships to function, evolution and disease. The meeting goal is to explore current advances and frontiers in structural biology and illustrate how high-throughput approaches in x-ray crystallography and NMR - in combination with hybrid methods using computational and other biophysical techniques (including CryoEM, Xray and Electron Tomography, SAXS, Mass Spectometry, Proteomics) - can be used to tackle topical and challenging problems in molecular, cellular and chemical biology. This symposium will focus on the variety of approaches and methodologies that are available to both structural biologists and biologists for investigation of biological systems and their component macromolecules and complexes. We will also address some topical issues of great relevance to the field through two open debates. The attendees will also have an opportunity to broaden their appreciation of the complex biological systems that can benefit from these current advances in structural biology via the sister meeting on Structure-Function- Biological Organization - which will share a keynote and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: The field of structural genomics encompasses cutting-edge experimental methods to determine the three- dimensional structure and function of proteins and other macromolecules. These technologies enable the scientific community to keep pace with the wealth of information derived from genome sequencing efforts. The Keystone Symposia meeting on High-Throughput Structural Biology will focus on how to address challenging proteins, biological systems and whole organisms, as well as how to fill the void in our knowledge of the protein universe that has become apparent from the vast numbers of genome sequences where the biological function is unknown.