Conologues: Ultra-fast-acting therapeutic insulins based on cone snail venom insulin principles
Conologues: Ultra-fast-acting therapeutic insulins based on cone snail venom insulin principles
批准号:
nhmrc : GNT1143546
负责人:
A/Pr Michael Lawrence
金额:
$108.29万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --
中文摘要
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英文摘要
The increasing prevalence of Type 1 and Type 2 diabetes demands better treatments. Our Project is based on a fascinating discovery by our international team of CIs of a new type of insulin within marine organisms that could form the basis of a novel diabetes therapeutic. Within our Project we will exploit this discovery to develop a new class of ultra-rapid-acting therapeutic insulins.
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会议论文
Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease
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批准号:nhmrc : 1099595
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项目类别:Project Grants
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资助金额:$51.59万
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财政年份:2016
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负责人:A/Pr Michael Lawrence
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依托单位:
Conformational change in insulin and Type I insulin-like growth factor receptor upon ligand binding
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批准号:nhmrc : 1070526
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项目类别:Project Grants
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资助金额:$27.7万
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财政年份:2014
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负责人:A/Pr Michael Lawrence
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依托单位:
Targeting the insulin and insulin-like growth factor receptors in cancer, diabetes and Alzheimer's disease
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批准号:nhmrc : 1058233
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项目类别:Project Grants
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资助金额:$66.23万
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财政年份:2014
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负责人:A/Pr Michael Lawrence
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依托单位:
Defining the active insulin conformation
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批准号:nhmrc : GNT1069328
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项目类别:Project Grants
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资助金额:$54.26万
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财政年份:2014
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负责人:A/Pr Michael Lawrence
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依托单位:
Signalling mechanisms in the insulin receptor family
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批准号:nhmrc : 1024869
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项目类别:Project Grants
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资助金额:$0.0万
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财政年份:2012
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负责人:A/Pr Michael Lawrence
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依托单位:
How insulin and the insulin-like growth factors bind to their receptors - the key role of the ?-chain C-terminal helix
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批准号:nhmrc : 1005896
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项目类别:Project Grants
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资助金额:$50.19万
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财政年份:2011
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负责人:A/Pr Michael Lawrence
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依托单位:
Structural Basis of Ligand Binding to Type 1 Insulin-like Growth Factor Receptor (IGF-1R)
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批准号:nhmrc : 575539
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项目类别:NHMRC Project Grants
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资助金额:$29.78万
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财政年份:2009
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负责人:A/Pr Michael Lawrence
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依托单位:
The Structural Basis of Ligand-Induced Activation of the Insulin Receptor
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批准号:nhmrc : 516729
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项目类别:NHMRC Project Grants
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资助金额:$42.73万
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财政年份:2008
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负责人:A/Pr Michael Lawrence
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依托单位:
国内基金
海外基金
磷脂酶Ultra特异性催化油脂体系中微量磷脂分子的调控机制研究
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批准号:31471690
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项目类别:面上项目
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资助金额:90.0万元
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批准年份:2014
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负责人:王永华
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依托单位:
适应纳米尺度CMOS集成电路DFM的ULTRA模型完善和偏差模拟技术研究
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批准号:60976066
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项目类别:面上项目
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资助金额:41.0万元
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批准年份:2009
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负责人:何进
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依托单位: