Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease

胰岛素和 IGF 信号传导中的结构事件 - 解决癌症、糖尿病和阿尔茨海默病问题的纳米圆盘方法

• 批准号: nhmrc : 1099595
• 负责人: A/Pr Michael Lawrence
• 金额: $ 51.59万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-events-insulin-alzheimers-disease/662462
• 关键词: Structural; events; insulin; IGF; signalling

Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.

胰岛素及其类胰岛素生长因子在澳大利亚老年人面临的三种主要疾病——糖尿病、癌症和阿尔茨海默病——中发挥着重要作用。我们的目标是了解这些蛋白质如何通过它们所谓的受体将信息发送到细胞中。我们将从细胞中分离出受体分子，然后在先进的电子显微镜中对它们进行成像以产生三维图像。我们的研究结果将对针对上述三种疾病的疗法的设计产生影响。