Conformational change in insulin and Type I insulin-like growth factor receptor upon ligand binding

配体结合后胰岛素和 I 型胰岛素样生长因子受体的构象变化

• 批准号: nhmrc : 1070526
• 负责人: A/Pr Michael Lawrence
• 金额: $ 27.7万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/conformational-change-insulin-ligand-binding/455433
• 关键词: Conformational; change; insulin; Type; like

Insulin and insulin-like growth factors bind to receptor molecules on the surfaces of cells. The binding event results in a signal being sent into the cell to initiate in the case of insulin, uptake of glucose into the cell and, in the case of the growth factors, normal human growth. Breakdown of these processes is implicated in a number of disease states, including diabetes, cancer and Alzheimer's disease. This Project aims to decipher the receptor triggering mechanism that is responsible for getting the signal into the cell.

胰岛素和胰岛素样生长因子与细胞表面的受体分子结合。结合事件导致信号被发送到细胞中，以在胰岛素的情况下启动葡萄糖摄取到细胞中，并且在生长因子的情况下启动正常的人生长。这些过程的破坏与许多疾病状态有关，包括糖尿病、癌症和阿尔茨海默病。该项目旨在破译负责将信号送入细胞的受体触发机制。