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Structural Basis of Ligand Binding to Type 1 Insulin-like Growth Factor Receptor (IGF-1R)

Structural Basis of Ligand Binding to Type 1 Insulin-like Growth Factor Receptor (IGF-1R)
配体与 1 型胰岛素样生长因子受体 (IGF-1R) 结合的结构基础
批准号:
nhmrc : 575539
负责人:
A/Pr Michael Lawrence
金额:
$29.78万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31

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中文摘要
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英文摘要
Insulin-like growth factors are involved in normal growth and development. However, they are also implicated in cancer development and progression. We are seeking to understand the way in which these growth factors bind to their receptor on the surface of the cell and stimulate the cell to survive, proliferate and migrate to new tumour sites. Such knowledge will be useful in the design of molecules that could potentially intervere with this process and thus be used as anti-cancer therapeutics.
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Conologues: Ultra-fast-acting therapeutic insulins based on cone snail venom insulin principles
  • 批准号:
    nhmrc : GNT1143546
  • 项目类别:
    Project Grants
  • 资助金额:
    $108.29万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Michael Lawrence
  • 依托单位:
Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease
Conformational change in insulin and Type I insulin-like growth factor receptor upon ligand binding
Targeting the insulin and insulin-like growth factor receptors in cancer, diabetes and Alzheimer's disease
国内基金
海外基金
基于Volatility Basis-set方法对上海大气二次有机气溶胶生成的模拟
  • 批准号:
    41105102
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2011
  • 负责人:
    王杨君
  • 依托单位:
求解Basis Pursuit问题的数值优化方法
  • 批准号:
    11001128
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    18.0万元
  • 批准年份:
    2010
  • 负责人:
    王丽平
  • 依托单位: