Structural Basis of Ligand Binding to Type 1 Insulin-like Growth Factor Receptor (IGF-1R)

配体与 1 型胰岛素样生长因子受体 (IGF-1R) 结合的结构基础

• 批准号: nhmrc : 575539
• 负责人: A/Pr Michael Lawrence
• 金额: $ 29.78万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-ligand-igf-1r/98878
• 关键词: Structural; Basis; Ligand; Binding; Type

Insulin-like growth factors are involved in normal growth and development. However, they are also implicated in cancer development and progression. We are seeking to understand the way in which these growth factors bind to their receptor on the surface of the cell and stimulate the cell to survive, proliferate and migrate to new tumour sites. Such knowledge will be useful in the design of molecules that could potentially intervere with this process and thus be used as anti-cancer therapeutics.

胰岛素样生长因子参与正常生长和发育。然而，它们也与癌症的发展和进展有关。我们正在寻求了解这些生长因子与细胞表面受体结合的方式，并刺激细胞存活，增殖和迁移到新的肿瘤部位。这些知识将有助于设计可能参与这一过程的分子，从而用作抗癌治疗剂。