Defining the active insulin conformation

定义活性胰岛素构象

• 批准号: nhmrc : GNT1069328
• 负责人: A/Pr Michael Lawrence
• 金额: $ 54.26万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-active-insulin-conformation/1344966
• 关键词: Defining; active; insulin; conformation

In 2011 there were over 360 million people with type 1 and type 2 diabetes worldwide, who will require insulin treatment. There is an urgent need for insulin analogues that provide effective control of blood glucose to avoid unwanted hypoglycemic or hyperglycemic events. We have developed two novel insulin analogues with unique properties and aim to understand their mechanism of action. This knowledge will present new opportunities for improved insulin mimetics for diabetes treatment.

2011年，全球有超过3.6亿人患有1型和2型糖尿病，他们需要胰岛素治疗。迫切需要能够有效控制血糖以避免不必要的低血糖或高血糖事件的胰岛素类似物。我们开发了两种具有独特特性的新型胰岛素类似物，旨在了解它们的作用机制。这些知识将为改进糖尿病治疗的胰岛素模拟物提供新的机会。