Signalling mechanisms in the insulin receptor family

胰岛素受体家族的信号传导机制

• 批准号: nhmrc : 1024869
• 负责人: A/Pr Michael Lawrence
• 金额: --
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-mechanisms-insulin-receptor-family/662336
• 关键词: Signalling; mechanisms; insulin; receptor; family

The receptor molecules that we are studying are involved in two disease states, namely, diabetes and cancer. These diseases are particularly relevant in the context of Australia's aging population. The task of these particular receptor molecules is to pass messages from the outside of cells to the interior of cells. We are seeking to understand, at the molecular level of detail, the way in which these messages are transferred, with the potential to lead to new avenues for therapeutic development in the context of these two diseases.

我们正在研究的受体分子涉及两种疾病状态，即糖尿病和癌症。这些疾病在澳大利亚人口老龄化的背景下尤为重要。这些特殊受体分子的任务是将信息从细胞外部传递到细胞内部。我们正在寻求在分子水平上详细了解这些信息传递的方式，有可能为这两种疾病的治疗开发带来新的途径。