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The Structural Basis of Ligand-Induced Activation of the Insulin Receptor

The Structural Basis of Ligand-Induced Activation of the Insulin Receptor
配体诱导的胰岛素受体激活的结构基础
批准号:
nhmrc : 516729
负责人:
A/Pr Michael Lawrence
金额:
$42.73万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

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中文摘要
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英文摘要
We aim to understand how insulin binds to and activates its cell-surface receptor. This information has implications for the design of anti-diabetic agents targetted directly to the insulin receptor. Diabetes is a global health problem and is classified by the World Health Organization as an epidemic. The results also have implications for the insulin-like growth factor receptor system and the design of anti-cancer therapeutics directed towards it .
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Conologues: Ultra-fast-acting therapeutic insulins based on cone snail venom insulin principles
  • 批准号:
    nhmrc : GNT1143546
  • 项目类别:
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  • 资助金额:
    $108.29万
  • 财政年份:
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  • 负责人:
    A/Pr Michael Lawrence
  • 依托单位:
Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease
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  • 批准号:
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  • 项目类别:
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  • 资助金额:
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