The Structural Basis of Ligand-Induced Activation of the Insulin Receptor

配体诱导的胰岛素受体激活的结构基础

• 批准号: nhmrc : 516729
• 负责人: A/Pr Michael Lawrence
• 金额: $ 42.73万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-ligand-insulin-receptor/94493
• 关键词: Structural; Basis; Ligand; Induced; Activation

We aim to understand how insulin binds to and activates its cell-surface receptor. This information has implications for the design of anti-diabetic agents targetted directly to the insulin receptor. Diabetes is a global health problem and is classified by the World Health Organization as an epidemic. The results also have implications for the insulin-like growth factor receptor system and the design of anti-cancer therapeutics directed towards it .

我们的目标是了解胰岛素如何与其细胞表面受体结合并激活。这一信息对直接针对胰岛素受体的抗糖尿病药物的设计具有重要意义。糖尿病是一个全球性的健康问题，被世界卫生组织列为流行病。这一结果也对胰岛素样生长因子受体系统和针对该系统的抗癌疗法的设计具有指导意义。