University of California, Irvine Cancer Center Support Grant

加州大学欧文分校癌症中心支持补助金

• 批准号: 8533453
• 负责人: FRANK L. MEYSKENS
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-11 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8533453
• 关键词: Biology; Biometry; California; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Clinical; Clinical Research; Comprehensive Cancer Center; County; Developmental Biology; Division of Basic Sciences; Epidemiologic Studies; Funding; Genotype; Goals; Growth Factor; Laboratory Research; Malignant Neoplasms; Mass Spectrum Analysis; Molecular Biology; Optics; Oranges; Participant; Peer Review; Phenotype; Population; Population Sciences; Prevention; Protein Microchips; Proteins; Reporting; Research; Research Activity; Resource Sharing; Screening for cancer; Signal Transduction; Societies; Spectrum Analysis; Students; Supportive care; Therapeutic; Tissues; Training; Training and Education; Transgenic Mice; Translations; Universities; University of California Irvine Cancer Center; biobehavior; cancer risk; carcinogenesis; in vivo; member; multidisciplinary; oncology; programs; science education; socioeconomics

DESCRIPTION (provided by applicant): The University of California, Irvine Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in Orange County and is a matrix-type organization. The Cancer Center serves approximately three million people in Orange County. The research goals of the Cancer Center are: 1) To contribute to the understanding of basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials, whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multicultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary, multidisciplinary, and transdisciplinary research. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control & Population Sciences, and Education & Training. The Divisions interact through seven research programs: Carcinogenesis, Developmental Biology, Growth Factors & Signaling, Onco-lmaging & Spectroscopy, Population Sciences, Structural Molecular Biology, and Translational Oncology. The Center provides centralized support for Program functions through ten Shared Resource Facilities: Biobehavioral, Biostatistics, Clinical Research Office, DMA Sequencing, DMA & Protein MicroArray, Experimental Tissue, In-Vivo Functional Onco-lmaging, Optical Biology, Protein Mass Spectrometry, and Transgenic Mouse. The Education & Training Division facilitates integration of students into basic, clinical, and cancer control research activities in the various programs and accordingly enhances the translational capabilities of the Center. The 143 full Members of the Center are currently supported by $11,909,249 in direct NCI funds. Of the overall direct total of cancer-related funding ($36,214,529), $30,665,383 is peer-reviewed and $5,549,146 is non-peer-reviewed. Cancer Center Members entered 202 participants on prevention, therapeutic, and supportive care trials in the 2006-07 reporting year.

描述(申请人提供)：加州大学欧文分校综合癌症中心是美国国立卫生研究院在奥兰治县唯一指定的综合癌症中心，是一个矩阵类型的组织。癌症中心为奥兰治县约300万人提供服务。癌症中心的研究目标是：1)促进对癌症表型和基因的基本机制的了解；2)促进实验室和流行病学研究转化为假说驱动的临床预防和治疗研究；3)进行临床预防试验，只要可能，由中心产生的研究成果；4)确定中心服务的不同社会经济和多元文化社会中的癌症风险，并制定研究战略，促进在这些人群中预防和早期发现癌症；5)利用各级提供的广泛的教育和培训机会作为主要的翻译工具，并鼓励开展促进跨学科、多学科和跨学科研究的活动。 该中心由四个主要部门组成：基础科学、临床研究、癌症控制和人口科学以及教育和培训。这些分部通过七个研究项目相互作用：癌症发生、发育生物学、生长因子和信号、肿瘤成像和光谱、人口科学、结构分子生物学和转译肿瘤学。该中心通过以下十个共享资源设施为项目功能提供集中支持：生物行为、生物统计学、临床研究办公室、DNA测序、DMA和蛋白质微阵列、实验组织、体内功能肿瘤成像、光学生物学、蛋白质质谱仪和转基因小鼠。教育与培训部促进学生参与各种计划中的基础、临床和癌症控制研究活动，并相应地增强中心的翻译能力。 该中心的143名正式成员目前由NCI的11,909,249美元的直接资金支持。在与癌症有关的直接供资总额(36,214,529美元)中，30,665,383美元是同行评审，5,549,146美元是非同行评审。癌症中心成员在2006-07报告年度参加了202名参与者的预防、治疗和支持性护理试验。