GESTATIONAL DIABETES LEADS TO CARDIOVASCULAR VULNERABILITY IN OFFSPRING

妊娠期糖尿病导致后代心血管脆弱

• 批准号: 8357786
• 负责人: KEVIN L GROVE
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357786
• 关键词: Adolescent; Animals; Cardiovascular Physiology; Cardiovascular system; Development; Diet; Fatty acid glycerol esters; Female; Fetus; Funding; Future; Gestational Diabetes; Grant; Health; Insulin Resistance; Lead; Maternal Health; Metabolic; Metabolic stress; Modeling; Monkeys; Mothers; National Center for Research Resources; Nutrient; Placenta; Plasma; Primates; Principal Investigator; Reactive Oxygen Species; Research; Research Infrastructure; Resources; Risk; Source; Staging; Structure; United States National Institutes of Health; cardiovascular disorder risk; cost; cytokine; offspring; pregnant; saturated fat

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is increasing evidence that abnormal maternal metabolic status exerts deleterious effects on the cardiovascular system of the fetus that may last for a lifetime. Gestational diabetes, for example, may lead to an altered maternal metabolic state characterized by abnormal plasma nutrient concentrations, increased cytokine levels and pro-oxidant profile. Abnormal placental structure and function and abnormal metabolic function of the placenta then follow. Thus the state of the mother becomes a metabolic stress to the fetus. We have discovered that pregnant female monkeys acquire gestational insulin resistance if they chronically consume a diet high in saturated fats for several years. The combination of poor maternal metabolic health and diet contribute to a broad range of health risks in the offspring. The purpose of these studies is to use the NHP model to investigate the effects maternal health and diet on the development of the cardiovascular system in the offspring. These studies will characterize: 1) pathological changes in the placenta and cardiovascular systems, 2) the cardiovascular function of the offspring at several developmental stages, and 3) microvascular function in juvenile offspring. These studies will help determine the future risk of cardiovascular disease for offspring of animals consuming a high fat diet.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 越来越多的证据表明，异常的母体代谢状况对胎儿的心血管系统产生有害影响，这可能会持续一生。 例如，妊娠糖尿病可能导致孕产妇代谢状态的改变，其特征在于血浆养分异常，细胞因子水平增加和促氧化剂谱。然后遵循胎盘的异常胎盘结构和功能和异常代谢功能。 因此，母亲的状态成为胎儿的代谢压力。我们已经发现，如果孕妇猴子长期食用饱和脂肪高的饮食持续数年，则会获得妊娠胰岛素抵抗。 不良的孕产妇代谢健康和饮食的结合在后代中造成了广泛的健康风险。 这些研究的目的是使用NHP模型来研究孕产妇健康和饮食对后代心血管系统发展的影响。 这些研究将表征：1）胎盘和心血管系统的病理变化，2）后代在几个发育阶段的心血管功能，以及3）少年后代的微血管功能。 这些研究将有助于确定心血管疾病的未来风险，即消耗高脂饮食的动物后代。