TREATMENT OF OBESITY AND INSULIN RESISTANCE IN THE NON-HUMAN PRIMATE
非人类灵长类动物肥胖和胰岛素抵抗的治疗
基本信息
- 批准号:8357811
- 负责人:
- 金额:$ 3.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgonistBody WeightBody mass indexCardiovascular PhysiologyChronicCoronary heart diseaseDiabetes MellitusDietDoseEatingEnergy IntakeEnergy MetabolismExpenditureFundingGrantHealthHealthcareHumanInsulin ResistanceMacaca mulattaMonkeysNational Center for Research ResourcesObesityPeripheralPersonsPhasePrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRiskSourceUnited States National Institutes of HealthWomanblood glucose regulationcosteconomic costheart disease riskimprovedinsightmennonhuman primateobesity treatmentphase 1 study
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Obesity is one of the major health risk facing the developed world, significantly increasing the risk of coronary disease, and of diabetes. It has recently been shown that for every "point" by which a person's body mass index (BMI) exceeds 25, there is an associated increase (5% in men and 7% in women) in the risk of cardiac disease. Beyond the terrible human costs there are significant economic costs associated with health care for such an obese population. An estimated 9.4% of US healthcare expenditure is directly related to "obesity and inactivity", while recent costs due to diabetes were estimated at $98 billion per annum. There are two main aims of this study: Phase 1 will determine the efficacy of peripheral melanocortin agonist treatment on food intake in rhesus macaques. These are exploratory studies to optimize dose given s.c. Phase 2 will determine if chronic eripheral melanocortin agonist treatment can reduce body weight and adiposity in diet-induced obese (DIO) monkeys. This study will also determine if changes in body weight are do to chronic changes in caloric intake and/or increased energy expenditure. Finally, these studies will determine if this chronic melanocortin treatment improves glucose homeostasis and cardiovascular function. These are extensive studies that will generate critical insight into the potential of melanocortin agonist as a therapy for human obesity and diabetes.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
肥胖是发达国家面临的主要健康风险之一,显著增加了冠心病和糖尿病的风险。最近的研究表明,一个人的体重指数(BMI)每超过25个“点”,心脏病的风险就会相应增加(男性5%,女性7%)。除了可怕的人力成本之外,还有与如此肥胖人口的医疗保健相关的重大经济成本。据估计,美国医疗保健支出的9.4%与“肥胖和不活动”直接相关,而最近由于糖尿病造成的费用估计为每年980亿美元。本研究有两个主要目的:第1阶段将确定外周黑皮质素激动剂治疗对恒河猴摄食量的疗效。这些是探索性研究,旨在优化s.c.给药剂量。第2阶段将确定长期外周黑皮质素激动剂治疗是否可以减轻饮食诱导的肥胖(DIO)猴的体重和肥胖。 这项研究还将确定体重的变化是否与热量摄入和/或能量消耗增加的慢性变化有关。 最后,这些研究将确定这种长期黑皮质素治疗是否能改善葡萄糖稳态和心血管功能。 这些是广泛的研究,将产生关键的洞察黑皮质素激动剂作为一种治疗人类肥胖和糖尿病的潜力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KEVIN L GROVE其他文献
KEVIN L GROVE的其他文献
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{{ truncateString('KEVIN L GROVE', 18)}}的其他基金
PROJECT 1: METABOLIC AND NEUROENDOCRINE RESPONSES TO ANDROGEN AND DIET
项目 1:雄激素和饮食的代谢和神经内分泌反应
- 批准号:
8510085 - 财政年份:2013
- 资助金额:
$ 3.63万 - 项目类别:
MATERNAL HIGH FAT DIET AND THE MELANOCORTIN SYSTEM IN THE OFFSPRING
母亲的高脂肪饮食和后代的黑皮质素系统
- 批准号:
8357879 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
GESTATIONAL DIABETES LEADS TO CARDIOVASCULAR VULNERABILITY IN OFFSPRING
妊娠期糖尿病导致后代心血管脆弱
- 批准号:
8357786 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
ACTIONS OF MELANOCORTIN AGONISTS IN OBESE PRIMATES
黑皮质素激动剂对肥胖灵长类动物的作用
- 批准号:
8357859 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
Molecular mechanisms underlying NHP pancreatic beta cell failure, and recovery
NHP 胰腺 β 细胞衰竭和恢复的分子机制
- 批准号:
8214751 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
THE EFFECT OF HUMANIZED ANTIBODIES TO ANGPTL4 ON TRIGLYERIDES & VLDL-LEVELS
ANGPTL4 人源化抗体对甘油三酯的影响
- 批准号:
8357857 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE
非人灵长类动物胎儿肝脏编程机制
- 批准号:
8357764 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
MATERNAL DIET MODIFIES THE FETAL PRIMATE EPIGENOME AND CIRCADIAN GENE EXPRESSION
母亲饮食改变胎儿灵长类表观基因组和昼夜节律基因表达
- 批准号:
8357765 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
NEUROENDOCRINE RESPONSE TO GASTRIC BYPASS IN NONHUMAN PRIMATES
非人类灵长类动物胃绕道的神经内分泌反应
- 批准号:
8357861 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
HIGH FAT DIET INDUCED ALTERATIONS IN GENE EXPRESSION IN THE NONHUMAN PRIMATE
高脂肪饮食引起非人类灵长类动物基因表达的改变
- 批准号:
8357812 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
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